Laboratory of Molecular Biology, Nutrition and Biotechnology (Nutrigenomics) , University of the Balearic Islands (UIB) and Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición (CIBEROBN) , 07122 Palma de Mallorca , Spain.
Institut d'Investigació Sanitària Illes Balears (IdISBa) , 07120 Palma de Mallorca , Spain.
J Agric Food Chem. 2019 Apr 3;67(13):3633-3642. doi: 10.1021/acs.jafc.9b00296. Epub 2019 Mar 20.
Detrimental metabolic programming has become a determinant factor in obesity propensity and the development of metabolic disorders; therefore, the search of nutritional strategies to reverse it is very relevant. Pectin is a prebiotic with health-promoting effects, such as control of glucose homeostasis and lipid metabolism, although other possible health effects and the prevention of obesity have been poorly studied. We studied the effects of chronic physiological supplementation with high-esterified pectin (HEP) in the reversion of metabolic nutrition-sensitive malprogramming associated with gestational undernutrition. As a model of nutrition-sensitive malprogramming, we used the progeny of rats with mild calorie restriction (CR) during pregnancy and analyzed their performance under metabolic stress (high-sucrose diet). We focused on the study of the sensitivity to the main adipostatic/adipokine hormones, i.e., leptin, insulin, and adiponectin, at both peripheral (liver and circulating parameters) and central (hypothalamus) levels. Our main findings suggest that chronic HEP supplementation is able to prevent weight/fat gain, to substantially reverse the detrimental malprogramming caused by the CR condition, to improve general health circulating markers, to modulate oxidative/lipogenic balance in the liver and energy metabolism regulators in the hypothalamus, and to restore/improve adipostatic/adipokine sensitivity affected by maternal calorie restriction, both peripherally and centrally. HEP stands out as a food component potentially useful against the development of metabolic disorders and obesity.
有害的代谢编程已成为肥胖倾向和代谢紊乱发展的决定因素；因此，寻找可逆转它的营养策略非常重要。果胶是一种具有促进健康作用的益生元，例如控制葡萄糖稳态和脂质代谢，尽管其他可能的健康影响和肥胖预防的研究还很少。我们研究了慢性生理补充高酯化果胶（HEP）对与妊娠期营养不良相关的代谢营养敏感编程逆转的影响。作为营养敏感编程的模型，我们使用妊娠期间轻度热量限制（CR）的大鼠后代，并在代谢应激（高蔗糖饮食）下分析它们的表现。我们专注于研究主要的脂肪激素/脂肪因子，即瘦素、胰岛素和脂联素的敏感性，包括外周（肝脏和循环参数）和中枢（下丘脑）水平。我们的主要发现表明，慢性 HEP 补充能够防止体重/脂肪增加，大大逆转 CR 条件引起的有害编程，改善一般健康的循环标志物，调节肝脏中的氧化/脂肪生成平衡和下丘脑的能量代谢调节剂，并恢复/改善受母体热量限制影响的脂肪激素/脂肪因子敏感性，包括外周和中枢。HEP 作为一种食品成分，具有预防代谢紊乱和肥胖的潜力。
