Department of Biotechnology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana-Ambala, Haryana, 133207, India.
Department of Medical Laboratory Technology, University Institute of Applied Health Sciences, Chandigarh University, Gharuan, Mohali, 140413, Punjab, India.
Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb;396(2):191-212. doi: 10.1007/s00210-022-02298-0. Epub 2022 Oct 10.
Oroxylin A (OA), a well-known constituent of the root of Scutellariae plants, has been used in ethnomedicine already for centuries in treating various neoplastic disorders. However, only recent molecular studies have revealed the different mechanisms behind its action, demonstrating antiproliferative, anti-inflammatory, and proapoptotic effects, restricting also the spread of cancer cells to distant organs. A variety of cellular targets and modulated signal transduction pathways regulated by OA have been determined in diverse cells derived from different malignant tissues. In this review article, these anticancer activities are thoroughly described, representing OA as a potential lead structure for the design of novel more potent anticancer medicines. In addition, co-effects of this natural compound with conventional anticancer agents are analyzed and the advantages provided by nanotechnological methods for more efficient application of OA are discussed. In this way, OA might represent an excellent example of using ethnopharmacological knowledge for designing modern medicines.
梓醇 A（OA）是黄芩植物根部的一种著名成分，已经在传统医学中使用了几个世纪，用于治疗各种肿瘤疾病。然而，只有最近的分子研究揭示了其作用背后的不同机制，表明其具有抗增殖、抗炎和促凋亡作用，还可以限制癌细胞向远处器官的扩散。OA 在源自不同恶性组织的多种细胞中确定了多种细胞靶标和调节的信号转导途径。在这篇综述文章中，详细描述了这些抗癌活性，将 OA 作为设计新型更有效的抗癌药物的潜在先导结构。此外，还分析了这种天然化合物与传统抗癌药物的协同作用，并讨论了纳米技术方法为更有效地应用 OA 提供的优势。通过这种方式，OA 可能代表了利用民族药理学知识设计现代药物的一个极好范例。
