Institute of Clinical Medicine College, Guangzhou University of Chinese Medicine, Guangzhou 510000, Guangdong Province, China; Central Laboratory, Linyi People's Hospital, Linyi 276000, Shandong Province, China.
Central Laboratory, Linyi People's Hospital, Linyi 276000, Shandong Province, China; Linyi Key Laboratory of Tumor Biology, Linyi 276000, Shandong Province, China.
Int Immunopharmacol. 2022 Nov;112:109235. doi: 10.1016/j.intimp.2022.109235. Epub 2022 Oct 7.
Lymphoma is a common hematologic malignant tumor that originates from lymph nodes or other lymphoid tissues. The tumor microenvironment (TME) plays an indispensable role in tumorigenesis, tumor development, metastasis, relapse, and drug resistance. Macrophages, which are considered as critical immune cells in the TME, influence the development of tumors. In particular, M2-like tumor-associated macrophages (TAMs) promote lymphoma growth and worsen patient prognosis. Owing to their important roles in lymphoma, TAMs hold promise as biomarkers or targets for tumor immunotherapy. In this review, we summarize the origin, recruitment, polarization, function, and mechanism of action of TAMs in lymphoma to identify potential therapeutic targets and other strategies for patients with lymphoma.
淋巴瘤是一种常见的血液恶性肿瘤，起源于淋巴结或其他淋巴组织。肿瘤微环境（TME）在肿瘤发生、肿瘤发展、转移、复发和耐药性方面起着不可或缺的作用。巨噬细胞被认为是 TME 中的关键免疫细胞，影响肿瘤的发展。特别是，M2 样肿瘤相关巨噬细胞（TAMs）促进淋巴瘤的生长并恶化患者的预后。由于 TAMs 在淋巴瘤中的重要作用，它们有望成为肿瘤免疫治疗的生物标志物或靶点。在这篇综述中，我们总结了 TAMs 在淋巴瘤中的起源、募集、极化、功能和作用机制，以确定潜在的治疗靶点和其他淋巴瘤患者的治疗策略。
