State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Statistics, The University of Auckland, Auckland, New Zealand.
Chemosphere. 2023 Jan;310:136764. doi: 10.1016/j.chemosphere.2022.136764. Epub 2022 Oct 7.
Microplastics (MP) and nanoplastics (NP) have been found in multiple environments and creatures. However, their effects on the airway microbiota still remain poorly understood. In this study, a series of bioinformatic and statistical analyses were carried out to explore the influence of airborne MP and NP on the nasal and lung microbiota in mice. Both MP and NP were capable of inducing nasal microbial dysbiosis, and MP had a stronger influence on the lung microbiota than NP. Multiple nasal and lung bacteria were associated with MP and NP groups, among which nasal Staphylococcus and lung Roseburia were most associated with MP group, while nasal Prevotella and lung unclassified_Muribaculaceae were most associated with NP group. The nasal Staphylococcus, lung Roseburia, lung Eggerthella and lung Corynebacterium were associated with both MP and NP groups, which were potential biomarkers of micro/nanoplastics-induced airway dysbiosis. SAR11_Clade_Ia and SAR11_Clade_II were associated with both nasal and lung microbiota in MP group, while no such bacterium was determined in NP group. The relevant results suggest that both airborne MP and NP could induce nasal and lung microbial dysbiosis, and the relevant preventative and curable strategies deserve further investigations.
微塑料 (MP) 和纳米塑料 (NP) 已在多种环境和生物中被发现。然而，它们对气道微生物群的影响仍知之甚少。在这项研究中，进行了一系列生物信息学和统计学分析，以探究空气中的 MP 和 NP 对小鼠鼻腔和肺部微生物群的影响。MP 和 NP 均能诱导鼻腔微生物失调，且 MP 对肺部微生物群的影响强于 NP。多种鼻腔和肺部细菌与 MP 和 NP 组相关，其中鼻腔葡萄球菌和肺部罗斯伯里氏菌与 MP 组相关性最强，而鼻腔普雷沃氏菌和肺部未分类的 Muribaculaceae 与 NP 组相关性最强。鼻腔葡萄球菌、肺部罗斯伯里氏菌、肺部 Eggerthella 和肺部棒状杆菌与 MP 和 NP 组均相关，它们是微/纳米塑料诱导气道失调的潜在生物标志物。SAR11_Clade_Ia 和 SAR11_Clade_II 与 MP 组的鼻腔和肺部微生物群均相关，而 NP 组未确定此类细菌。相关结果表明，空气中的 MP 和 NP 均可诱导鼻腔和肺部微生物失调，相关的预防和治疗策略值得进一步研究。
