State Key Laboratory for Diagnosis and Treatment of Infectious Disease, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Department of Rehabilitation, Shulan (Hangzhou) Hospital, Zhejiang Shuren University School of Medicine, Hangzhou, China.
J Hazard Mater. 2023 Jan 5;441:129903. doi: 10.1016/j.jhazmat.2022.129903. Epub 2022 Sep 6.
Microplastics (MP) and nanoplastics (NP) exist in the disposable plastic take-away containers. This study aims to determine the gut and oral microbiota alterations in the individuals frequently and occasionally consuming take-away food in disposable plastic containers (TFDPC), and explore the effect of micro/nanoplastics (MNP) reduction on gut microbiota in mice. TFDPC consumption are associated with greater presences of gastrointestinal dysfunction and cough. Both occasional and frequent consumers have altered gut and oral microbiota, and their gut diversity and evenness are greater than those of non-TFDPC consuming cohort. Multiple gut and oral bacteria are associated with TFDPC consumers, among which intestinal Collinsella and oral Thiobacillus are most associated with the frequent consumers, while intestinal Faecalibacterium is most associated with the occasional consumers. Although some gut bacteria associated with the mice treated with 500 µg NP and 500 µg MP are decreased in the mice treated with 200 µg NP, the gut microbiota of the three MNP groups are all different from the control group. This study demonstrates that TFDPC induces gut and oral microbiota alterations in the consumers, and partial reduction of the size and amount of MNP cannot rectify the MNP-induced gut microbial dysbiosis.
微塑料（MP）和纳米塑料（NP）存在于一次性塑料外卖容器中。本研究旨在确定经常和偶尔食用一次性塑料外卖容器（TFDPC）的个体的肠道和口腔微生物群的改变，并探索减少微/纳米塑料（MNP）对小鼠肠道微生物群的影响。TFDPC 的消费与胃肠道功能障碍和咳嗽的更大存在有关。偶尔和经常食用者的肠道和口腔微生物群均发生改变，其肠道多样性和均匀度大于非 TFDPC 食用者。多种肠道和口腔细菌与 TFDPC 消费者有关，其中肠道柯林斯菌和口腔硫杆菌与频繁消费者最相关，而肠道粪杆菌与偶尔消费者最相关。尽管用 500µg NP 和 500µg MP 处理的小鼠中一些与肠道相关的细菌减少，但用 200µg NP 处理的小鼠的肠道微生物群与对照组均不同。本研究表明，TFDPC 会引起消费者的肠道和口腔微生物群改变，而 MNP 大小和数量的部分减少不能纠正 MNP 引起的肠道微生物失调。
