Webster N R, Toothill C
Clin Chim Acta. 1987 Aug 31;167(3):259-65. doi: 10.1016/0009-8981(87)90345-7.
Red cell structure and function were examined in rats exposed to 80% oxygen: 20% nitrogen for five days and compared with red cells from air-breathing animals. Evidence of red cell destruction was noted in the animals exposed to hyperoxia. Osmotic fragility was found to be reduced in red cells from oxygen exposed rats (p less than 0.05), also, red cell haemolysis in hydrogen peroxide was noted to be greater (p less than 0.001) in these animals. Inorganic phosphate ion transport was significantly reduced (p less than 0.001) in the red cells from rats receiving oxygen for 5 days. The results demonstrate a decreased ability of the red cell to transport anions and suggest an impairment of the normal movement of water across the membrane following exposure to oxygen.
对暴露于80%氧气和20%氮气环境中5天的大鼠的红细胞结构和功能进行了检测，并与呼吸空气动物的红细胞进行了比较。在暴露于高氧环境的动物中发现了红细胞破坏的证据。发现暴露于氧气的大鼠的红细胞渗透脆性降低（p<0.05），此外，这些动物在过氧化氢中的红细胞溶血现象更明显（p<0.001）。接受氧气5天的大鼠的红细胞中无机磷酸离子转运显著降低（p<0.001）。结果表明红细胞运输阴离子的能力下降，并提示暴露于氧气后水跨膜的正常运动受到损害。
