红细胞水通透性。麻醉醇类的作用及膜胆固醇水平的改变。

Erythrocyte water permeability. The effects of anesthetic alcohols and alterations in the level of membrane cholesterol.

Kutchai H, Cooper R A, Forster R E

Biochim Biophys Acta. 1980 Aug 4;600(2):542-52. doi: 10.1016/0005-2736(80)90455-1.

Abstract

Treatment of human erythrocytes with anesthetic n-alkanols (pentanol, hexanol and hepatanol) results in a decrease in the osmotic water permeability of the red cell membrane. 2. The alcohol-induced changes in osmotic water permeability are proportional to the alcohol concentration and roughly parallel diphenylhexatriene that are induced by the alcohols. 3. Enrichment of the red cell membrane in cholesterol also results in a decrease in the osmotic water permeability. 4. Moderate depletion (9% or 40%) of membrane cholesterol is without effect on the osmotic water permeability, even though this treatment results in a significant increase in the rotational mobility of diphenylhexatriene in the membrane lipids.

摘要

用麻醉性正链烷醇（戊醇、己醇和庚醇）处理人体红细胞会导致红细胞膜的渗透水通透性降低。2. 酒精诱导的渗透水通透性变化与酒精浓度成正比，并且大致与酒精诱导的二苯基己三烯平行。3. 红细胞膜中胆固醇的富集也会导致渗透水通透性降低。4. 膜胆固醇的适度消耗（9%或40%）对渗透水通透性没有影响，尽管这种处理会导致膜脂中二苯基己三烯的旋转流动性显著增加。