Center of Reproductive Medicine, Shengjing Hospital of China Medical University, Shenyang, China.
Shenyang Reproductive Health Clinical Medicine Research Center, Shenyang, China.
Sci Rep. 2022 Oct 10;12(1):16993. doi: 10.1038/s41598-022-20574-0.
The essence of enterotypes is stratifying the entire human gut microbiome, which modulates the association between diet and disease risk. A study was designed at the Center of Reproductive Medicine, Shengjing Hospital of China Medical University and Jinghua Hospital of Shenyang. Prevotella and Bacteroides were analyzed in 407 samples of stool, including 178 men with enterotype B (61 normal, 117 overweight/obese) and 229 men with enterotype P (74 normal, 155 overweight/obese). The ratio between Prevotella and Bacteroides abundance, P/B, was used as a simplified way to distinguish the predominant enterotype. In enterotype P group (P/B ≥ 0.01), obesity was a risk factor for a reduced rate of forward progressive sperm motility (odds ratio [OR] 3.350; 95% confidence interval [CI] 1.881-5.966; P < 0.001), and a reduced rate of total sperm motility (OR 4.298; 95% CI 2.365-7.809; P < 0.001). Obesity was also an independent risk factor (OR 3.131; 95% CI 1.749-5.607; P < 0.001) after adjusting follicle-stimulating hormone. In enterotype P, body mass index, as a diagnostic indicator of a reduced rate of forward progressive sperm motility and a decreased rate of decreased total sperm motility, had AUC values of 0.627 (P = 0.001) and 0.675 (P < 0.0001), respectively, which were significantly higher than the predicted values in all patients. However, in enterotype B group (P < 0.01), obesity was not a risk factor for asthenospermia, where no significant difference between obesity and sperm quality parameters was observed. This study is tried to introduce enterotypes as a population-based individualized classification index to investigate the correlation between BMI and asthenospermia. In our study, overweight/obese men with enterotype P were found to have poorer sperm quality. however, sperm quality was not associated with overweight/obese in men with enterotype B. Thereof, BMI is a risk factor for asthenospermia only in men with enterotype P, but not in men with enterotype B.
肠型的本质是对整个人类肠道微生物组进行分层，这调节了饮食与疾病风险之间的关联。这项研究是在中国医科大学盛京医院生殖医学中心和沈阳京华医院设计的。分析了 407 份粪便样本中的普雷沃氏菌属和拟杆菌属，包括 178 名肠型 B 的男性（61 名正常，117 名超重/肥胖）和 229 名肠型 P 的男性（74 名正常，155 名超重/肥胖）。Prevotella 和 Bacteroides 丰度的比值，即 P/B，被用作区分主要肠型的简化方法。在肠型 P 组（P/B≥0.01）中，肥胖是精子前向运动活力降低（比值比[OR]3.350；95%置信区间[CI]1.881-5.966；P<0.001）和总精子活力降低（OR 4.298；95%置信区间[CI]2.365-7.809；P<0.001）的危险因素。肥胖也是调整卵泡刺激素后的独立危险因素（OR 3.131；95%置信区间[CI]1.749-5.607；P<0.001）。在肠型 P 中，体重指数作为精子前向运动活力降低和总精子活力降低的诊断指标，其 AUC 值分别为 0.627（P=0.001）和 0.675（P<0.0001），明显高于所有患者的预测值。然而，在肠型 B 组（P<0.01）中，肥胖并不是弱精子症的危险因素，肥胖与精子质量参数之间没有显著差异。本研究试图引入肠型作为一种基于人群的个体化分类指标，研究 BMI 与弱精子症之间的相关性。在我们的研究中，发现肠型 P 的超重/肥胖男性精子质量较差。然而，在肠型 B 的男性中，体重指数与精子质量参数无关。因此，BMI 只是肠型 P 男性弱精子症的危险因素，而不是肠型 B 男性弱精子症的危险因素。
