Instituto de Neurociencias de Castilla y León (INCYL), Departamento de Bioquímica y Biología Molecular, Universidad de Salamanca, Instituto de Investigación Biomédica de Salamanca (IBSAL), Calle Pintor Fernando Gallego 1, Salamanca, 37007, Spain.
Oncogene. 2022 Nov;41(45):4917-4928. doi: 10.1038/s41388-022-02487-4. Epub 2022 Oct 10.
Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during proliferation, migration, stemness and differentiation. Src is a node of several signals involved in many of these biological processes, and it is also an important regulator of cell metabolism. Glucose uptake, glycolysis, the pentose-phosphate pathway and oxidative phosphorylation are among the metabolic pathways that can be regulated by Src. Therefore, this oncoprotein is in an excellent position to coordinate and finely tune cell metabolism to fuel the different cancer cell activities. Here, we provide an up-to-date summary of recent progress made in determining the role of Src in glucose metabolism as well as the link of this role with cancer cell metabolic plasticity and tumour progression. We also discuss the opportunities and challenges facing this field.
代谢必须受到严格的调控，以满足癌细胞在增殖、迁移、干性和分化过程中的动态需求。Src 是参与许多这些生物过程的几个信号的节点，也是细胞代谢的重要调节剂。葡萄糖摄取、糖酵解、磷酸戊糖途径和氧化磷酸化是可以被 Src 调节的代谢途径之一。因此，这种癌蛋白处于协调和微调细胞代谢以为不同的癌细胞活动提供燃料的绝佳位置。在这里，我们提供了关于 Src 在葡萄糖代谢中的作用以及该作用与癌细胞代谢可塑性和肿瘤进展之间联系的最新进展的最新总结。我们还讨论了该领域面临的机遇和挑战。
