Department of Oral Surgery and Implantology, Carolinum, Goethe University, Frankfurt, Germany.
Buser Consulting Services, Gümligen, Switzerland.
J Clin Periodontol. 2023 Feb;50(2):232-241. doi: 10.1111/jcpe.13734. Epub 2022 Oct 19.
To histologically evaluate the influence of (1) loading and (2) grafting on osseointegration and peri-implant soft-tissue healing at immediately placed, self-cutting progressive tissue-level implants (TLX) in a minipig model.
TLX implants (n = 56) were immediately placed following the extraction of the mandibular first and second premolars, bilaterally, in a total of n = 14 minipigs. In each animal, the implant sites were allocated to the following four groups: (1) unloaded with simultaneous grafting using a bovine bone mineral; (2) unloaded without grafting; (3) loaded with simultaneous grafting; and (4) loaded without grafting. Histomorphometric assessments at 4 and 12 weeks (n = 7 animals each) included primary (i.e., bone-to-implant contact [BIC]) and secondary outcome measures (e.g., first BIC [fBIC], junctional epithelium length [JE], connective tissue contact length [CTC], biological width [BW = JE + CTC]).
At 4 weeks, mean BIC values ranged from 74.5 ± 11.6% in Group 2 to 83.8 ± 13.3% in Group 1, and, at 12 weeks, from 75.5% ± 7.9% in Group 2 to 79.9 ± 8.6% in Group 1. Multivariate linear mixed regression did not reveal any associations between BIC and implant loading or grafting at 4 and 12 weeks. At 12 weeks, significantly higher fBIC values were noted in Group 2 when compared with Group 1. All groups showed comparable JE, CTC, and BW values.
Implant loading and grafting had no major effects on osseointegration and peri-implant soft tissue healing at TLX implants.
通过小型猪模型，评估（1）负载和（2）移植物对即刻植入自切渐进式组织水平种植体（TLX）的骨整合和种植体周围软组织愈合的影响。
TLX 种植体（n=56）在下颌第一和第二前磨牙拔除后即刻植入，双侧共 n=14 只小型猪。在每只动物中，种植部位被分为以下 4 组：（1）不负载，同时使用牛骨矿物质进行移植；（2）不负载，不进行移植；（3）负载，同时进行移植；（4）负载，不进行移植。4 周和 12 周（每组各 7 只动物）的组织学评估包括主要（即骨与种植体接触[BIC]）和次要（如初次 BIC[fBIC]、结合上皮长度[JE]、结缔组织接触长度[CTC]、生物学宽度[BW=JE+CTC]）测量。
4 周时，BIC 值从第 2 组的 74.5±11.6%到第 1 组的 83.8±13.3%，12 周时，从第 2 组的 75.5±7.9%到第 1 组的 79.9±8.6%。多元线性混合回归分析显示，在 4 周和 12 周时，BIC 与种植体负载或移植之间无相关性。在 12 周时，与第 1 组相比，第 2 组的 fBIC 值显著更高。所有组的 JE、CTC 和 BW 值均无显著差异。
TLX 种植体的负载和移植对骨整合和种植体周围软组织愈合无明显影响。
