软组织对聚醚醚酮（PEEK）或钛制成的牙种植体封闭帽的反应。
Soft tissue response to dental implant closure caps made of either polyetheretherketone (PEEK) or titanium.
机构信息
Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Robert K. Schenk Laboratory of Oral Histology, School of Dental Medicine, University of Bern, Bern, Switzerland.
出版信息
Clin Oral Implants Res. 2019 Aug;30(8):808-816. doi: 10.1111/clr.13487. Epub 2019 Jun 12.
OBJECTIVE
Polyetheretherketone (PEEK) is a popular synthetic thermoplastic polymer for medical applications, but its clinical use suffers from several limitations. Therefore, the aim was to compare the soft tissue response to dental implant closure caps made of PEEK or titanium as evaluated by the occurrence of multinucleated giant cells (MNGCs).
MATERIAL AND METHODS
Forty-two implants were placed in the maxilla of seven miniature pigs. While commercially pure titanium (Ti) implants had a Ti closure cap, ceramic implants made of either zirconia (Zr) or alumina-toughened zirconia (Zr + Al) received a PEEK closure cap. Histomorphometry was performed to evaluate the number of small and large MNGCs being in contact with the PEEK or the Ti in different compartments of the implant systems.
RESULTS
No histological signs of inflammation were noticed, and MNGCs were observed on both PEEK and Ti closure caps and on all three implant types. Significantly higher numbers of MNGCs were found on closure caps made of PEEK than on closure caps made of Ti on the external closure cap surface facing both soft (p = 0.0008 for PEEK on Zr and p = 0.0016 for PEEK on Zr + Al) and hard tissues (p = 0.016 for PEEK on Zr and p = 0.003 for PEEK on Zr + Al) as well as in the internal closure cap surface (p = 0.014 for PEEK on Zr and p = 0.0088 for PEEK on Zr + Al). No statistically significant differences in the number of MNGCs were observed on the three implant types.
CONCLUSIONS
Significantly more MNGCs were in contact with PEEK than with Ti closure caps.
目的
聚醚醚酮（PEEK）是一种常用于医学应用的合成热塑性聚合物，但由于其临床应用存在一些局限性。因此，本研究旨在比较使用多聚核巨细胞（MNGCs）评估的 PEEK 和钛牙种植体封闭帽的软组织反应。
材料与方法
将 42 个种植体植入 7 只小型猪的上颌骨。纯钛（Ti）商业种植体使用 Ti 封闭帽，氧化锆（Zr）或氧化铝增韧氧化锆（Zr+Al）陶瓷种植体使用 PEEK 封闭帽。进行组织形态计量学分析以评估与 PEEK 或 Ti 接触的小和大 MNGCs 数量，以及不同种植体系统各部位。
结果
未观察到组织学炎症迹象，在 PEEK 和 Ti 封闭帽上以及所有三种种植体类型上都观察到 MNGCs。在外部封闭帽表面朝向软、硬组织（PEEK 在 Zr 上为 p=0.0008，PEEK 在 Zr+Al 上为 p=0.0016；PEEK 在 Zr 上为 p=0.016，PEEK 在 Zr+Al 上为 p=0.003）以及内部封闭帽表面（PEEK 在 Zr 上为 p=0.014，PEEK 在 Zr+Al 上为 p=0.0088），PEEK 封闭帽的 MNGCs 数量明显高于 Ti 封闭帽。在三种种植体类型上，MNGCs 的数量无统计学差异。
结论
与 Ti 封闭帽相比，与 PEEK 接触的 MNGCs 明显更多。
Zotero 插件