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限时进食结合或不结合低碳水化合物饮食可减少内脏脂肪并改善代谢综合征：一项随机试验。

Time-restricted eating with or without low-carbohydrate diet reduces visceral fat and improves metabolic syndrome: A randomized trial.

机构信息

Department of Endocrinology, The First Affiliated Hospital of Xi'an JiaoTong University, No. 277, West Yanta Road, Xi'an, Shaanxi 710061, P.R. China.

Department of Endocrinology and International Medical Center, The First Affiliated Hospital of Xi'an JiaoTong University, No. 277, West Yanta Road, Xi'an, Shaanxi 710061, P.R. China.

出版信息

Cell Rep Med. 2022 Oct 18;3(10):100777. doi: 10.1016/j.xcrm.2022.100777. Epub 2022 Oct 10.

DOI:10.1016/j.xcrm.2022.100777
PMID:36220069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9589024/
Abstract

Overconsumption of carbohydrate-rich food combined with adverse eating patterns contributes to the increasing incidence of metabolic syndrome (MetS) in China. Therefore, we conducted a randomized trial to determine the effects of a low-carbohydrate diet (LCD), an 8-h time-restricted eating (TRE) schedule, and their combination on body weight and abdominal fat area (i.e., primary outcomes) and cardiometabolic outcomes in participants with MetS. Compared with baseline, all 3-month treatments significantly reduce body weight and subcutaneous fat area, but only TRE and combination treatment reduce visceral fat area (VFA), fasting blood glucose, uric acid (UA), and dyslipidemia. Furthermore, compared with changes of LCD, TRE and combination treatment further decrease body weight and VFA, while only combination treatment yields more benefits on glycemic control, UA, and dyslipidemia. In conclusion, without change of physical activity, an 8-h TRE with or without LCD can serve as an effective treatment for MetS (ClinicalTrials.gov: NCT04475822).

摘要

碳水化合物摄入过多与不良的饮食习惯相结合，导致中国代谢综合征（MetS）发病率不断上升。因此，我们进行了一项随机试验，以确定低碳水化合物饮食（LCD）、8 小时限时进食（TRE）方案及其组合对 MetS 患者的体重和腹部脂肪面积（即主要结果）以及心脏代谢结果的影响。与基线相比，所有 3 个月的治疗均显著降低体重和皮下脂肪面积，但仅 TRE 和联合治疗可降低内脏脂肪面积（VFA）、空腹血糖、尿酸（UA）和血脂异常。此外，与 LCD 的变化相比，TRE 和联合治疗进一步降低体重和 VFA，而只有联合治疗在血糖控制、UA 和血脂异常方面更有获益。总之，在不改变身体活动的情况下，8 小时 TRE 联合或不联合 LCD 可作为治疗 MetS 的有效方法（ClinicalTrials.gov：NCT04475822）。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/a6b7ae2e57e8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/4ebf05bb627d/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/8070c847646e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/199ab4fdcc8b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/a6b7ae2e57e8/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/4ebf05bb627d/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/8070c847646e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/199ab4fdcc8b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/239a/9589024/a6b7ae2e57e8/gr3.jpg

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