From the Department of Endocrinology and Metabolism (D.L., Y.H., C.H., X.W., P.Z., D.G., J.L., B.X., S.L., Y.X., H.Z.) and the Department of Nutrition (S.Y., L.S.), Nanfang Hospital, Southern Medical University, Guangzhou, China; and the Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans (C.L., H.H., J.H.).
N Engl J Med. 2022 Apr 21;386(16):1495-1504. doi: 10.1056/NEJMoa2114833.
BACKGROUND: The long-term efficacy and safety of time-restricted eating for weight loss are not clear. METHODS: We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) with calorie restriction or daily calorie restriction alone. For 12 months, all the participants were instructed to follow a calorie-restricted diet that consisted of 1500 to 1800 kcal per day for men and 1200 to 1500 kcal per day for women. The primary outcome was the difference between the two groups in the change from baseline in body weight; secondary outcomes included changes in waist circumference, body-mass index (BMI), amount of body fat, and measures of metabolic risk factors. RESULTS: Of the total 139 participants who underwent randomization, 118 (84.9%) completed the 12-month follow-up visit. The mean weight loss from baseline at 12 months was -8.0 kg (95% confidence interval [CI], -9.6 to -6.4) in the time-restriction group and -6.3 kg (95% CI, -7.8 to -4.7) in the daily-calorie-restriction group. Changes in weight were not significantly different in the two groups at the 12-month assessment (net difference, -1.8 kg; 95% CI, -4.0 to 0.4; P = 0.11). Results of analyses of waist circumferences, BMI, body fat, body lean mass, blood pressure, and metabolic risk factors were consistent with the results of the primary outcome. In addition, there were no substantial differences between the groups in the numbers of adverse events. CONCLUSIONS: Among patients with obesity, a regimen of time-restricted eating was not more beneficial with regard to reduction in body weight, body fat, or metabolic risk factors than daily calorie restriction. (Funded by the National Key Research and Development Project [No. 2018YFA0800404] and others; ClinicalTrials.gov number, NCT03745612.).
背景：限时进食减肥的长期疗效和安全性尚不清楚。
方法：我们将 139 名肥胖患者随机分为限时进食（仅在上午 8 点至下午 4 点之间进食）加热量限制组或单纯热量限制组。所有参与者在 12 个月内均遵循热量限制饮食，男性每天摄入 1500 至 1800 千卡，女性每天摄入 1200 至 1500 千卡。主要结局为两组间体重从基线的变化差异；次要结局包括腰围、体重指数（BMI）、体脂肪量和代谢危险因素测量值的变化。
结果：在总共接受随机分组的 139 名参与者中，有 118 名（84.9%）完成了 12 个月的随访。在 12 个月时，限时进食组的体重从基线下降了 8.0 公斤（95%置信区间[CI]，-9.6 至 -6.4），而每日热量限制组下降了 6.3 公斤（95%CI，-7.8 至 -4.7）。两组在 12 个月评估时的体重变化无显著差异（净差异，-1.8 公斤；95%CI，-4.0 至 0.4；P=0.11）。腰围、BMI、体脂肪量、体瘦组织量、血压和代谢危险因素的分析结果与主要结局结果一致。此外，两组间不良事件的数量也无明显差异。
结论：在肥胖患者中，限时进食方案在减轻体重、体脂肪或代谢危险因素方面并不优于每日热量限制。（由国家重点研发计划[编号：2018YFA0800404]等资助；ClinicalTrials.gov 编号，NCT03745612。）
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