限时进食对超重和肥胖女性和男性体重减轻及其他代谢参数的影响：TREAT 随机临床试验。
Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity: The TREAT Randomized Clinical Trial.
机构信息
Cardiovascular Research Institute, University of California, San Francisco, San Francisco.
Cardiology Division, University of California, San Francisco, San Francisco.
出版信息
JAMA Intern Med. 2020 Nov 1;180(11):1491-1499. doi: 10.1001/jamainternmed.2020.4153.
IMPORTANCE
The efficacy and safety of time-restricted eating have not been explored in large randomized clinical trials.
OBJECTIVE
To determine the effect of 16:8-hour time-restricted eating on weight loss and metabolic risk markers.
INTERVENTIONS
Participants were randomized such that the consistent meal timing (CMT) group was instructed to eat 3 structured meals per day, and the time-restricted eating (TRE) group was instructed to eat ad libitum from 12:00 pm until 8:00 pm and completely abstain from caloric intake from 8:00 pm until 12:00 pm the following day.
DESIGN, SETTING, AND PARTICIPANTS: This 12-week randomized clinical trial including men and women aged 18 to 64 years with a body mass index (BMI, calculated as weight in kilograms divided by height in meters squared) of 27 to 43 was conducted on a custom mobile study application. Participants received a Bluetooth scale. Participants lived anywhere in the United States, with a subset of 50 participants living near San Francisco, California, who underwent in-person testing.
MAIN OUTCOMES AND MEASURES
The primary outcome was weight loss. Secondary outcomes from the in-person cohort included changes in weight, fat mass, lean mass, fasting insulin, fasting glucose, hemoglobin A1c levels, estimated energy intake, total energy expenditure, and resting energy expenditure.
RESULTS
Overall, 116 participants (mean [SD] age, 46.5 [10.5] years; 70 [60.3%] men) were included in the study. There was a significant decrease in weight in the TRE (-0.94 kg; 95% CI, -1.68 to -0.20; P = .01), but no significant change in the CMT group (-0.68 kg; 95% CI, -1.41 to 0.05, P = .07) or between groups (-0.26 kg; 95% CI, -1.30 to 0.78; P = .63). In the in-person cohort (n = 25 TRE, n = 25 CMT), there was a significant within-group decrease in weight in the TRE group (-1.70 kg; 95% CI, -2.56 to -0.83; P < .001). There was also a significant difference in appendicular lean mass index between groups (-0.16 kg/m2; 95% CI, -0.27 to -0.05; P = .005). There were no significant changes in any of the other secondary outcomes within or between groups. There were no differences in estimated energy intake between groups.
CONCLUSIONS AND RELEVANCE
Time-restricted eating, in the absence of other interventions, is not more effective in weight loss than eating throughout the day.
TRIAL REGISTRATION
ClinicalTrials.gov Identifiers: NCT03393195 and NCT03637855.
重要性
限时进食的疗效和安全性尚未在大型随机临床试验中得到探索。
目的
确定 16:8 小时限时进食对体重减轻和代谢风险标志物的影响。
干预措施
参与者被随机分组，即规律进餐时间（CMT）组被指示每天吃 3 顿有结构的餐，限时进食（TRE）组被指示从中午 12:00 点开始自由进食，直到第二天 8:00 点，完全禁止摄入卡路里。从 8:00 点到 12:00 点。
设计、设置和参与者：这项为期 12 周的随机临床试验纳入了年龄在 18 岁至 64 岁之间、体重指数（BMI，计算为体重（千克）除以身高（米）的平方）在 27 至 43 之间的男性和女性，参与者使用定制的移动研究应用程序进行研究。参与者使用蓝牙秤。参与者居住在美国各地，其中有 50 名参与者居住在加利福尼亚州旧金山附近，他们接受了现场测试。
主要结果和测量
主要结果是体重减轻。现场队列的次要结果包括体重、体脂肪量、去脂体重、空腹胰岛素、空腹血糖、糖化血红蛋白水平、估计能量摄入、总能量消耗和静息能量消耗的变化。
结果
共有 116 名参与者（平均[标准差]年龄 46.5[10.5]岁；70[60.3%]名男性）参与了这项研究。 TRE 组体重明显下降（-0.94kg；95%CI，-1.68 至 -0.20；P=0.01），而 CMT 组体重无明显变化（-0.68kg；95%CI，-1.41 至 0.05，P=0.07）或组间差异无统计学意义（-0.26kg；95%CI，-1.30 至 0.78；P=0.63）。在现场队列（n=25 TRE，n=25 CMT）中，TRE 组的体重明显下降（-1.70kg；95%CI，-2.56 至 -0.83；P<0.001）。组间也有显著的四肢去脂体重指数差异（-0.16kg/m2；95%CI，-0.27 至 -0.05；P=0.005）。组内和组间其他次要结果均无显著变化。组间估计能量摄入无差异。
结论和相关性
在没有其他干预措施的情况下，限时进食在减肥方面并不比全天进食更有效。
试验注册
ClinicalTrials.gov 标识符：NCT03393195 和 NCT03637855。
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