遗传性视网膜疾病的自适应光学成像
Adaptive Optics Imaging of Inherited Retinal Disease.
机构信息
Department of Ophthalmology, University of California, San Francisco, California 94143-4081, USA.
Department of Ophthalmology & Visual Sciences, Medical College of Wisconsin Eye Institute, Milwaukee, Wisconsin 53226, USA
出版信息
Cold Spring Harb Perspect Med. 2023 Jul 5;13(7):a041285. doi: 10.1101/cshperspect.a041285.
The human retina is amenable to direct, noninvasive visualization using a wide array of imaging modalities. In the ∼140 years since the publication of the first image of the living human retina, there has been a continued evolution of retinal imaging technology. Advances in image acquisition and processing speed now allow real-time visualization of retinal structure, which has revolutionized the diagnosis and management of eye disease. Enormous advances have come in image resolution, with adaptive optics (AO)-based systems capable of imaging the retina with single-cell resolution. In addition, newer functional imaging techniques provide the ability to assess function with exquisite spatial and temporal resolution. These imaging advances have had an especially profound impact on the field of inherited retinal disease research. Here we will review some of the advances and applications of AO retinal imaging in patients with inherited retinal disease.
人类视网膜可以通过各种成像方式进行直接、无创的可视化。自第一篇活体人类视网膜图像发表以来的大约 140 年中，视网膜成像技术不断发展。图像采集和处理速度的进步现在允许实时可视化视网膜结构，这彻底改变了眼病的诊断和治疗。图像分辨率也取得了巨大进步，基于自适应光学（AO）的系统能够以单细胞分辨率成像视网膜。此外，更新的功能成像技术提供了以精细的空间和时间分辨率评估功能的能力。这些成像进展对遗传性视网膜疾病研究领域产生了特别深远的影响。在这里，我们将回顾 AO 视网膜成像在遗传性视网膜疾病患者中的一些进展和应用。
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