Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, University of Campania Luigi Vanvitelli, Via: L. Armanni 5, 80131, Naples, Italy.
Medical Center, Centro Sociale ex Canapificio, Caserta, Italy.
Infection. 2022 Dec;50(6):1565-1572. doi: 10.1007/s15010-022-01938-0. Epub 2022 Oct 12.
Since few data are available in the literature on the prevalence of anti-Delta-positive subjects in immigrant populations, the aim of the present study was to evaluate the demographic and virological characteristics of HDV infection in a large cohort of immigrants living in southern Italy.
Between January 2012 and February 2020 all immigrants attending one of the 5 first- level centers were enrolled and screened for HBsAg, the HBsAg-positive for anti-Delta and if positive, for HDV-RNA and HDV genotype.
Of the 3521 immigrants observed in the study period, 3417 (97.0%) agreed to be screened; they were mainly males (61%), with a median age of 27 years (IQR 8-74) and came prevalently (58%) from sub-Saharan Africa. Of the 3417 patients enrolled, 319 (9%) subjects were HBsAg-positive, and of those, 8 (2.5%) were anti-Delta-positive. No difference in the demographic and epidemiological characteristics was observed between the anti-Delta-negative vs -positive. Of the 8 anti-Delta-positive subjects, only one was HDV-RNA-positive (viral load: 7050 IU/mL), genotype 1, with clinical signs of cirrhosis.
the present study showed a prevalence of HDV of 2.5% in a large cohort of asymptomatic immigrants, suggesting the need for screening campaigns for viral infections including delta hepatitis in this population.
由于文献中关于移民人群中抗-Delta 阳性者的流行率数据较少，本研究旨在评估意大利南部一个大型移民群体中 HDV 感染的人口统计学和病毒学特征。
2012 年 1 月至 2020 年 2 月，所有在 5 个一级中心就诊的移民均入组并接受 HBsAg 筛查，HBsAg 阳性者检测抗-Delta，如为阳性，则进一步检测 HDV-RNA 和 HDV 基因型。
在研究期间观察到的 3521 名移民中，3417 名（97.0%）同意接受筛查；他们主要为男性（61%），中位年龄为 27 岁（IQR 8-74），主要来自撒哈拉以南非洲（58%）。3417 名入组患者中，319 名（9%）为 HBsAg 阳性，其中 8 名（2.5%）为抗-Delta 阳性。抗-Delta 阴性与阳性患者在人口统计学和流行病学特征方面无差异。在 8 名抗-Delta 阳性患者中，仅 1 名患者的 HDV-RNA 呈阳性（病毒载量：7050 IU/mL），基因型 1，伴有肝硬化的临床症状。
本研究在一个大型无症状移民群体中显示出 HDV 的流行率为 2.5%，提示在该人群中需要针对包括 delta 肝炎在内的病毒感染进行筛查活动。
