Clinic for Pediatrics III, Department of Pediatric Hematology/Oncology, West German Cancer Centre, University Hospital Essen, Hufelandstraße 55, 45122, Essen, Germany.
Institute for Sports and Sports Science, Karlsruhe Institute of Technology, 76131, Karlsruhe, Germany.
J Cancer Res Clin Oncol. 2023 Jul;149(8):4719-4729. doi: 10.1007/s00432-022-04392-5. Epub 2022 Oct 12.
Sufficient physical activity (PA) has the potential to mitigate late effects of cancer, but objective data of PA levels in adolescents are scarce. The aim of this study was to investigate differences in PA behavior between childhood cancer survivors (CCS) and healthy peers.
PA levels of n = 74 CCS and n = 1304 healthy peers from the MoMo study aged 9-15 years were assessed with validated objective accelerometry and group means were compared. A binary multiple logistic regression was performed to investigate the potential predictors of PA.
CCS spent significantly more time sedentary (p < 0.001) and less time in moderate-to-vigorous physical activity (p = 0.002) compared to the healthy cohort. Subgroup analysis revealed the largest deviations of PA levels for CCS aged 9-11 years who fulfilled international PA recommendations on significantly fewer days than MoMo (p < 0.01). Health conditions seem to be a predictor concerning the fulfillment of international PA recommendations by the WHO (p = 0.015).
Our study identified vulnerable groups which seem to require targeted exercise and health behavior change programs to increase physical activity and reduce sedentary time. The presence of treatment sequelae as a significant predictor of insufficient physical activity underlines the need of multidisciplinary supportive care approaches.
足够的身体活动（PA）有减轻癌症晚期影响的潜力，但青少年 PA 水平的客观数据很少。本研究旨在调查癌症幸存者（CCS）和健康同龄人之间 PA 行为的差异。
使用经过验证的客观加速度计评估了 n = 74 名 CCS 和 n = 1304 名来自 MoMo 研究的 9-15 岁健康同龄人的 PA 水平，并比较了组平均值。进行了二元多项逻辑回归分析，以调查 PA 的潜在预测因素。
与健康队列相比，CCS 久坐时间明显更长（p < 0.001），中高强度体力活动时间明显更短（p = 0.002）。亚组分析显示，满足国际 PA 建议的 9-11 岁 CCS 组的 PA 水平偏差最大，比 MoMo 少满足国际 PA 建议的天数明显更多（p < 0.01）。健康状况似乎是 WHO 国际 PA 建议达标（p = 0.015）的一个预测因素。
我们的研究确定了一些弱势群体，他们似乎需要有针对性的运动和健康行为改变计划来增加体力活动和减少久坐时间。治疗后遗症作为体力活动不足的重要预测因素，强调了需要采用多学科支持性护理方法。
