Ivory Brittany J, Moore Kristen, Dinalo Jennifer E, Ness Kirsten K, Orgel Etan, Dieli-Conwright Christina M, Kadan-Lottick Nina S, Freyer David R, Belcher Britni R
Cancer and Blood Disease Institute, Children's Hospital Los Angeles, Los Angeles, California, USA
Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
BMJ Open. 2025 Aug 11;15(8):e100965. doi: 10.1136/bmjopen-2025-100965.
Excessive sedentary behaviour (SB) is highly prevalent among children and adolescents and young adults (AYAs) treated for cancer. Although SB is associated with adverse health outcomes in adults with cancer, little is known about SB in younger cancer patients and survivors. In this scoping review, we aim to summarise current literature on (1) the association between SB and clinical outcomes and (2) results of intervention trials to reduce SB, specifically in paediatric and AYA cancer patients and survivors.
The scoping review will follow the five stages described in the Arksey and O'Malley methodology framework. We will conduct a comprehensive search in five varied electronic databases (PubMed, Embase, Web of Science, CINAHL and SportDiscus) for original articles published in peer-reviewed journals since 1 January 2000, and search reference lists of identified articles and previous review articles. All original research article types will be considered (ie, cross-sectional, cohort, interventional trials). Two reviewers will independently screen all articles based on predetermined inclusion and exclusion criteria, including (1) more than half the sample at the time of study must have been children (0-14 years old) and/or adolescent and young adults (AYAs, 15-39-year old) who were being or had been previously treated for cancer and (2) reporting of SB. Data will be extracted as a descriptive and quantitative summary of each study's key characteristics and results. Study-specific quality assessment will be performed using established tools. Results will be presented in evidence tables with an accompanying narrative summary.
Ethics approval is not required as only publicly available data will be analysed. Results will be published in a peer-reviewed journal and may be presented at a scientific conference.
The protocol is registered in Open Science Framework (https://osf.io/ua8z9).
久坐行为（SB）过多在接受癌症治疗的儿童、青少年及青年成人（AYA）中极为普遍。尽管久坐行为与成年癌症患者的不良健康结局相关，但对于较年轻的癌症患者及幸存者的久坐行为却知之甚少。在本范围综述中，我们旨在总结关于以下两方面的当前文献：（1）久坐行为与临床结局之间的关联；（2）减少久坐行为的干预试验结果，特别是针对儿科及AYA癌症患者和幸存者。
范围综述将遵循阿克西和奥马利方法框架中描述的五个阶段。我们将在五个不同的电子数据库（PubMed、Embase、科学网、护理学与健康领域数据库及体育文献数据库）中全面检索自2000年1月1日以来在同行评审期刊上发表的原创文章，并检索已识别文章及先前综述文章的参考文献列表。将考虑所有原创研究文章类型（即横断面研究、队列研究、干预试验）。两名评审员将根据预先确定的纳入和排除标准独立筛选所有文章，这些标准包括：（1）研究时样本中超过一半必须是儿童（0 - 14岁）和/或青少年及青年成人（AYA，15 - 39岁），他们正在接受或曾经接受过癌症治疗；（2）对久坐行为的报告。数据将作为每项研究关键特征和结果的描述性及定量总结进行提取。将使用既定工具进行研究特异性质量评估。结果将在证据表中呈现，并附带叙述性总结。
由于仅分析公开可用数据，因此无需伦理批准。结果将发表在同行评审期刊上，并可能在科学会议上展示。
该方案已在开放科学框架（https://osf.io/ua8z9）中注册。
