Rodríguez-Pérez María Del Cristo, Kontro Titta Katariina, Almeida González Delia, Gómez Álvarez Beatriz, Marcelino Rodríguez Itahisa, Cabrera de León Y Antonio
Unidad de Investigación de Atención Primaria y del Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
Sección de Inmunología. Hospital Universitario Nuestra Señora de Candelaria, Santa Cruz de Tenerife, Spain.
J Exerc Sci Fit. 2022 Oct;20(4):366-371. doi: 10.1016/j.jesf.2022.09.002. Epub 2022 Sep 17.
Irisin is a myokine with a potential role in cardiometabolic diseases, but previous studies have described inconsistencies between serum irisin and physical activity (PA). Our aim was to analyze the relationship between serum irisin and leisure-time PA (LTPA) in a large sample of the general adult population, and secondarily, to evaluate its relationship with two PA-related biomarkers (HDL cholesterol and resistin).
A cross-sectional study was nested in the "CDC of the Canary Islands" cohort participants (n = 3827, 18-75 years, 60% women).
PA was collected by administering the Minnesota leisure-time physical activity questionnaire, and physical examination and blood tests (irisin, resistin, HDL-cholesterol) were performed.
Irisin inversely correlated with BMI (p < 0.001 in women) and resistin (p = 0.038 in women, p = 0.004 in men), and directly with HDL cholesterol (p < 0.001in women). There was a direct association of irisin with leisure-time and energy expenditure in light, moderate and vigorous LTPA, which was stronger in women than men. The distribution of leisure-time and PA variables across irisin quintiles showed a significant trend, except for light LPTA in men. Adjusting for age, sex and BMI, the association of irisin with leisure-time and LTPA variables was stronger than the association of these variables with resistin and HDL cholesterol, reaching the strongest association for irisin with the 80th percentile of time of LTPA (OR = 2.57; 95% CI = 2.00-3.31).
There is a direct and independent association between serum irisin levels and LTPA in the general adult population, which is stronger than other biomarkers of PA. Findings on exercise-related irisin support the possibility of irisin health benefits.
鸢尾素是一种肌动蛋白，在心脏代谢疾病中可能发挥作用，但先前的研究表明血清鸢尾素与身体活动（PA）之间存在不一致性。我们的目的是分析一般成年人群大样本中血清鸢尾素与休闲时间身体活动（LTPA）之间的关系，其次，评估其与两种与PA相关的生物标志物（高密度脂蛋白胆固醇和抵抗素）的关系。
一项横断面研究嵌套于“加那利群岛疾病预防控制中心”队列参与者（n = 3827，18 - 75岁，60%为女性）中。
通过发放明尼苏达休闲时间身体活动问卷收集PA，并进行体格检查和血液检测（鸢尾素、抵抗素、高密度脂蛋白胆固醇）。
鸢尾素与体重指数呈负相关（女性p < 0.001），与抵抗素呈负相关（女性p = 0.038，男性p = 0.004），与高密度脂蛋白胆固醇呈正相关（女性p < 0.001）。鸢尾素与轻度、中度和剧烈LTPA中的休闲时间和能量消耗呈正相关，女性的相关性强于男性。除男性轻度LPTA外，鸢尾素五分位数组中休闲时间和PA变量的分布呈现显著趋势。调整年龄、性别和体重指数后，鸢尾素与休闲时间和LTPA变量的关联强于这些变量与抵抗素和高密度脂蛋白胆固醇的关联，鸢尾素与LTPA时间第80百分位数的关联最强（比值比 = 2.57；95%置信区间 = 2.00 - 3.31）。
在一般成年人群中，血清鸢尾素水平与LTPA之间存在直接且独立的关联，且强于PA的其他生物标志物。与运动相关的鸢尾素研究结果支持鸢尾素对健康有益的可能性。
