Immunology Section, Nuestra Señora de Candelaria University Hospital, Santa Cruz de Tenerife, Canary Island, Spain.
Research Unit, Nuestra Señora de Candelaria University Hospital and Primary Care, Santa Cruz de Tenerife, Canary Islands, Spain.
Front Endocrinol (Lausanne). 2023 Jun 28;14:1193110. doi: 10.3389/fendo.2023.1193110. eCollection 2023.
Irisin is a myokine that increases with leisure time physical activity (LTPA) and for which a cardiovascular protective role has been postulated. Our aim was to assess this role in the general population.
A cross-sectional analysis was performed in a large randomly selected population sample (n=2298 women and 1529 men). Apart from age and sex, we record anthropometrics (blood pressure, heart rate, obesity), lifestyle (LTPA, smoking, alcohol), and biochemical measurements (irisin, lipid profile, insulin resistance). Correlations and regression multivariate models were used to analyze the association of irisin levels with the studied factors.
The variables more strongly and directly associated with irisin, adjusting the studied factors separately in women and men, were HOMA-2 (p=0.043 and p=0.001, respectively) and LTPA (p<0.001 and p=0.001, respectively). Also heart rate inversely (p=0.005 and p=0.002, respectively) and DBP directly (p<0.005 and p=0.045, respectively) were associated to irisin in both sexes. The waist/height ratio (p<0.001) was inversely associated to irisin only in women, and the alcohol drinking was directly associated (p=0.029) only in men.
We provide new findings for irisin, such as its association with DBP and with heart rate; furthermore, in women irisin is associated to abdominal obesity, and in men is associated to the alcohol intake. We also corroborate the association of irisin with LTPA and insulin resistance. The associations detected point towards a protective role of irisin in the maintenance of cardiometabolic health.
鸢尾素是一种肌因子，随着休闲时间体力活动（LTPA）增加，其具有心血管保护作用。我们的目的是在普通人群中评估这种作用。
对一个大型随机选择的人群样本（n=2298 名女性和 1529 名男性）进行了横断面分析。除年龄和性别外，我们还记录了人体测量学（血压、心率、肥胖）、生活方式（LTPA、吸烟、饮酒）和生化测量值（鸢尾素、血脂谱、胰岛素抵抗）。使用相关和多元回归模型分析了鸢尾素水平与所研究因素的关系。
在女性和男性中，分别单独调整所研究因素后，与鸢尾素关系更密切和直接的变量是 HOMA-2（p=0.043 和 p=0.001）和 LTPA（p<0.001 和 p=0.001）。心率也呈负相关（p=0.005 和 p=0.002），而 DBP 则直接相关（p<0.005 和 p=0.045）。在两性中，腰围/身高比（p<0.001）与鸢尾素呈负相关，而饮酒则与鸢尾素呈正相关（p=0.029）。
我们提供了鸢尾素的新发现，例如其与 DBP 和心率的关系；此外，在女性中，鸢尾素与腹部肥胖有关，而在男性中，鸢尾素与饮酒有关。我们还证实了鸢尾素与 LTPA 和胰岛素抵抗的关系。所检测到的关联表明鸢尾素在维持心血管代谢健康方面具有保护作用。
