Puolijoki H, Lahdensuo A
Eur J Respir Dis. 1987 Aug;71(2):77-85.
The aim of this study was to discover the subsequent histories and ultimate diagnoses in 182 patients studied in a chest clinic because of unexplained cough. Twenty-nine patients (16%) developed asthma during the mean follow-up time of 4.4 years. Chronic bronchitis was diagnosed in 18 patients (10%) and sporadic instances of some other diseases were also seen. The development of asthma was studied both by calculating simple relative risks and using a multiple logistic model. Circadian changes in peak expiratory flow (PEF)-values and total blood eosinophil count were found to be the best variables for predicting the risk of developing asthma in a patient with unexplained cough, whereas mild bronchial hyperreactivity had only a low predictive value. If the risk of developing asthma in a patient presenting with unexplained cough is to be estimated, attention should be paid simultaneously to a number of variables. Even mild abnormalities in several variables can be significant when they occur together.
本研究的目的是了解182例因不明原因咳嗽而在胸部门诊接受检查的患者的后续病史及最终诊断结果。在平均4.4年的随访期内，29例患者（16%）患上了哮喘。18例患者（10%）被诊断为慢性支气管炎，还发现了其他一些疾病的散发病例。通过计算简单相对风险和使用多元逻辑模型对哮喘的发生情况进行了研究。发现呼气峰值流速（PEF）值和全血嗜酸性粒细胞计数的昼夜变化是预测不明原因咳嗽患者发生哮喘风险的最佳变量，而轻度支气管高反应性的预测价值较低。如果要估计不明原因咳嗽患者发生哮喘的风险，应同时关注多个变量。当几个变量同时出现轻度异常时，即使异常程度较轻也可能具有重要意义。
