N-杂环卡宾催化的偕烯醇化物加成反应到 3-氰基-2-亚氨基-2-色烯：C 功能化 2-氨基-3-氰基-4-色烯的合成。
N-Heterocyclic carbene-catalysed homoenolate addition reaction to 3-cyano-2-imino-2-chromenes: synthesis of C-functionalized 2-amino-3-cyano-4-chromene.
机构信息
Department of Chemistry, Indira Gandhi National Tribal University, Amarkantak-484886, Madhya Pradesh, India.
出版信息
Org Biomol Chem. 2022 Nov 2;20(42):8203-8208. doi: 10.1039/d2ob01447e.
PMID:36226989
Abstract
A diastereoselective N-heterocyclic carbene-catalysed reaction between enal and 3-cyano-2-imino-2-chromene is described for accessing a new type of C-functionalized 2-amino-3-cyano-4-chromene. A wide variety of enals and iminochromenes afforded the desired homoenolate addition product 2-amino-4-chromenes in good yields and with moderate to good diastereoselectivities.
摘要
描述了一种 N-杂环卡宾催化的醛和 3-氰基-2-亚氨基-2-色烯之间的非对映选择性反应，用于构建新型 C 官能化的 2-氨基-3-氰基-4-色烯。各种醛和亚氨基色烯以中等至良好的非对映选择性和良好的收率得到所需的偕烯醇化物加成产物 2-氨基-4-色烯。
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