Vissicchio Nicholas A, Altaras Caroline, Seng Elizabeth K, Swencionis Charles, Picone MaryAnn, Foley Frederick W
Ferkauf Graduate School of Psychology, Yeshiva University.
Multiple Sclerosis Comprehensive Care Center, Holy Name Medical Center.
Rehabil Psychol. 2023 Feb;68(1):43-52. doi: 10.1037/rep0000467. Epub 2022 Oct 13.
The current study attempted to expand the literature on cognition and mood in MS by determining if illness intrusiveness may potentially serve as an intermediary factor in the well-established cognition-mood relationship in people with MS.
This study employed a retrospective cross-sectional design to answer this question. Baseline neuropsychological test data and mood questionnaires from 199 participants with clinically definite MS were used in this study. The sample was middle-aged ( = 48.4, = 11.8), highly educated ( = 14.6, = 2.2), majority female (76.9%) and majority White (74.5%). Assumptions for parametric statistics and ordinary least squares regression were met. Conditional process models evaluated whether illness intrusiveness mediated the relationship between cognitive functioning and psychiatric symptoms.
In total, 33.2% of the sample met criteria for clinically significant anxiety, 41.7% met criteria for depression, and 27.8% of the sample met criteria for processing speed impairment, consistent with other MS samples. Illness intrusiveness was found to mediate the relationship between processing speed and depression, ab = -.07, 95% CI [-.15, -.002], processing speed and anxiety, ab = -.06, 95% CI [-.12, -.02], and processing speed and more general mood disturbance, ab = -.08, 95% CI [-.13, -.0005].
Illness intrusiveness was found to be a potential important intermediary mechanism by which the primary cognitive impairment in MS, processing speed, impacts mood in this disease population. Conclusions, treatment implications, and directions for future research in light of these findings were discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).
本研究试图通过确定疾病侵扰是否可能作为多发性硬化症（MS）患者中已确立的认知与情绪关系的中介因素，来扩展关于MS认知与情绪的文献。
本研究采用回顾性横断面设计来回答这个问题。本研究使用了199名临床确诊为MS患者的基线神经心理学测试数据和情绪问卷。样本为中年（平均年龄 = 48.4岁，标准差 = 11.8岁），受教育程度高（平均受教育年限 = 14.6年，标准差 = 2.2年），大多数为女性（76.9%），大多数为白人（74.5%）。满足参数统计和普通最小二乘法回归的假设。条件过程模型评估疾病侵扰是否介导了认知功能与精神症状之间的关系。
总体而言，33.2%的样本符合临床显著焦虑标准，41.7%符合抑郁标准，27.8%的样本符合处理速度受损标准，这与其他MS样本一致。发现疾病侵扰介导了处理速度与抑郁之间的关系，间接效应ab = -0.07，95%置信区间[-0.15, -0.002]；处理速度与焦虑之间的关系，间接效应ab = -0.06，95%置信区间[-0.12, -0.02]；以及处理速度与更普遍的情绪困扰之间的关系，间接效应ab = -0.08，95%置信区间[-0.13, -0.0005]。
发现疾病侵扰是MS中主要认知障碍即处理速度影响该疾病人群情绪的一个潜在重要中介机制。根据这些发现讨论了结论、治疗意义和未来研究方向。（PsycInfo数据库记录（c）2023美国心理学会，保留所有权利）
