芬太尼与社交互动选择程序对环境和药理学操作的敏感性。
Sensitivity of a fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations.
机构信息
Department of Medicinal Chemistry, Virginia Commonwealth University, Richmond, VA, USA.
Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, VA, USA.
出版信息
Pharmacol Biochem Behav. 2022 Nov;221:173473. doi: 10.1016/j.pbb.2022.173473. Epub 2022 Oct 10.
Recent studies have shown that social interaction can serve as an alternative reinforcer to opioid self-administration under a choice context in rats. However, additional parametric studies are needed to evaluate the sensitivity of opioid-vs.-social interaction procedures relative to more established opioid-vs.-food procedures. The current study evaluated the sensitivity of a novel fentanyl-vs.-social interaction choice procedure to environmental and pharmacological manipulations previously shown to affect fentanyl-vs.-food choice. Male and female rats (responder rats; n = 6/sex) were trained to respond in a discrete-trial choice procedure for either 30-s access to a same-sex "partner" rat or an intravenous fentanyl infusion. Once trained, the effects of fentanyl unit dose (0, 0.32-10 μg/kg/inf), partner rat presence, opioid-dependence status, chronic naltrexone administration (0.032, 0.1 mg/kg/h), and response requirement for fentanyl self-administration (fixed ratio 1-320) were determined across weeks. The fentanyl-vs.-social interaction choice procedure was sensitive to the unit dose of fentanyl, chronic naltrexone treatment, and fentanyl response requirement. However, the magnitude of these effects on fentanyl choice was smaller than those reported in published fentanyl-vs.-food choice studies. Furthermore, fentanyl-vs.-social interaction choice was not sensitive to removal of the partner rat or opioid-dependence status. Minimal sex differences were detected. These results suggest that this fentanyl-vs.-social interaction choice procedure is less sensitive to environmental and pharmacological interventions than previously established opioid-vs.-food choice procedures. The observed discrepancy in sensitivity between the procedures suggests that social interaction may have qualitatively different reinforcing properties compared to more commonly assessed alternative reinforcers such as food (preclinical) or money (human laboratory).
最近的研究表明，在大鼠的选择情境下，社会互动可以作为阿片类药物自我给药的替代强化物。然而，需要进行更多的参数研究来评估阿片类药物与社会互动程序相对于更成熟的阿片类药物与食物程序的敏感性。本研究评估了一种新的芬太尼与社会互动选择程序对环境和药理学操作的敏感性，这些操作先前已被证明会影响芬太尼与食物的选择。雄性和雌性大鼠（应答大鼠；n=6/性别）接受训练，通过离散试验选择程序，可获得 30 秒与同性“伴侣”大鼠接触或静脉内芬太尼输注。一旦接受训练，就会确定芬太尼单位剂量（0、0.32-10μg/kg/inf）、伴侣大鼠存在、阿片类药物依赖状态、慢性纳曲酮给药（0.032、0.1mg/kg/h）以及芬太尼自我给药的反应要求（固定比率 1-320）的影响，这些影响在数周内确定。芬太尼与社会互动选择程序对芬太尼的单位剂量、慢性纳曲酮治疗和芬太尼反应要求敏感。然而，这些对芬太尼选择的影响的幅度小于已发表的芬太尼与食物选择研究报告的幅度。此外，芬太尼与社会互动选择对去除伴侣大鼠或阿片类药物依赖状态不敏感。检测到最小的性别差异。这些结果表明，与以前建立的阿片类药物与食物选择程序相比，这种芬太尼与社会互动选择程序对环境和药理学干预的敏感性较低。观察到的程序之间的敏感性差异表明，与更常评估的替代强化物（如食物（临床前）或金钱（人类实验室）相比，社会互动可能具有不同的强化性质。
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