Konturek S J, Radecki T, Piastucki I, Drozdowicz D
Digestion. 1987;37 Suppl 2:8-15. doi: 10.1159/000199553.
We investigated the gastroprotective effects of colloidal bismuth subcitrate (CBS, De-Nol) in comparison with agents such as sucralfate and methylated PGE2. Both CBS and sucralfate given orally prevented dose dependently the formation of gastric lesions by acidified aspirin, ethanol and restraint stress, CBS being more potent on a weight-to-weight basis than sucralfate. CBS and sucralfate were also equally effective in enhancing the healing rate of chronic gastric and duodenal ulcer induced by serosal application of acetic acid, while methylated PGE2 was completely ineffective in this model. Non-colloidal bismuth subnitrate, in contrast to CBS, was ineffective against stress-induced lesions. CBS stimulated mucosal generation and luminal release of PGE2 dose dependently.
我们研究了枸橼酸铋钾（CBS，得乐）与硫糖铝和甲基化前列腺素E2等药物相比的胃保护作用。口服CBS和硫糖铝均能剂量依赖性地预防酸化阿司匹林、乙醇和束缚应激所致胃损伤的形成，按重量计算，CBS比硫糖铝更有效。在提高由乙酸浆膜下注射诱导的慢性胃溃疡和十二指肠溃疡的愈合率方面，CBS和硫糖铝同样有效，而甲基化前列腺素E2在该模型中完全无效。与CBS相反，非胶体硝酸铋对应激诱导的损伤无效。CBS能剂量依赖性地刺激前列腺素E2的黏膜生成和腔内释放。
