枸橼酸铋钾（得乐）和硫糖铝的胃细胞保护作用。内源性前列腺素的作用。
Gastrocytoprotection by colloidal bismuth subcitrate (De-Nol) and sucralfate. Role of endogenous prostaglandins.
作者信息
Konturek S J, Radecki T, Piastucki I, Brzozowski T, Drozdowicz D
出版信息
Gut. 1987 Feb;28(2):201-5. doi: 10.1136/gut.28.2.201.
Abstract
This study compares the gastroprotective effects of colloidal bismuth subcitrate (De-Nol) with those of sucralfate and a methylated analogue of prostaglandin E2 (PGE2) against acute gastric lesions induced by acidified aspirin and absolute ethanol in rats. Both De-Nol and sucralfate given orally prevented dose dependently the formation of gastric lesions by these ulcerogens, De-Nol being, respectively, twice and seven times more potent, on a weight basis, than sucralfate. As the gastroprotective activities of both De-Nol and sucralfate on ethanol lesions can be reversed by pretreatment with indomethacin and as De-Nol and sucralfate increase the mucosal generation and luminal release of PGE2, we postulate that mucosal prostaglandins may be involved in the mechanism of action of these drugs on the gastric mucosa.
摘要
本研究比较了枸橼酸铋钾（得乐）、硫糖铝和前列腺素E2（PGE2）的甲基化类似物对大鼠酸化阿司匹林和无水乙醇诱导的急性胃损伤的胃保护作用。口服给予得乐和硫糖铝均能剂量依赖性地预防这些致溃疡物质引起的胃损伤形成，以重量计，得乐的效力分别是硫糖铝的两倍和七倍。由于吲哚美辛预处理可逆转得乐和硫糖铝对乙醇损伤的胃保护活性，且得乐和硫糖铝可增加胃黏膜中PGE2的生成和腔内释放，我们推测黏膜前列腺素可能参与了这些药物对胃黏膜的作用机制。
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本文引用的文献
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