Konturek S J, Radecki T, Piastucki I, Drozdowicz D
Scand J Gastroenterol Suppl. 1986;122:6-10. doi: 10.3109/00365528609102578.
This study was designed to compare the gastroprotective effects of colloidal bismuth subcitrate (CBS) with those of sucralfate and methylated analog of prostaglandin E2 (PGE2) against acute gastric lesions induced by absolute ethanol, acidified aspirin (ASA), and water immersion and restraint stress in rats. When given orally, both CBS and sucralfate prevented in a dose-dependent way the formation of gastric lesions induced by all three ulcerogens, CBS being about 7, 2, and 20 times more potent, respectively on a weight-to-weight basis than sucralfate. Methylated PGE2 was also highly effective against these ulcerogens. Bismuth subnitrate was ineffective against acute gastric lesions induced by stress conditions. The protection of both CBS and sucralfate was reversible when the animals were pretreated with indomethacin to suppress the generation of endogenous prostaglandins. Since CBS and sucralfate increased the production of PGE2 in the gastric mucosa, we postulate that their gastric protective action may be mediated, at least partly, by mucosal prostaglandins.
本研究旨在比较枸橼酸铋钾（CBS）、硫糖铝和前列腺素E2（PGE2）甲基化类似物对大鼠因无水乙醇、酸化阿司匹林（ASA）、水浸束缚应激诱导的急性胃损伤的胃保护作用。口服给药时，CBS和硫糖铝均能以剂量依赖的方式预防由这三种致溃疡剂诱导的胃损伤形成，以重量对重量计算，CBS的效力分别比硫糖铝高约7倍、2倍和20倍。甲基化PGE2对这些致溃疡剂也非常有效。硝酸铋对由应激条件诱导的急性胃损伤无效。当用吲哚美辛预处理动物以抑制内源性前列腺素的产生时，CBS和硫糖铝的保护作用均可逆转。由于CBS和硫糖铝增加了胃黏膜中PGE2的产生，我们推测它们的胃保护作用可能至少部分是由黏膜前列腺素介导的。
