Wang Yun, Tang Xiao-Jiao, Liu Qing, Chen Lin
Department of Ophthalmology, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation Base of Child Development and Critical Disorders, 136, Zhongshan 2nd Rd, Yuzhong District, Chongqing, 400014, China.
Ophthalmol Ther. 2023 Feb;12(1):87-98. doi: 10.1007/s40123-022-00590-z. Epub 2022 Oct 13.
This study aimed to investigate the incidence and risk factors for dry eye after pediatric strabismus surgery.
Children aged 5-12 years who underwent strabismus surgery were included in this single-center, prospective, cohort study. The ocular surface assessments were conducted 1 day before and 1, 4, and 8 weeks after surgery. The main outcome measures were the incidence of dry eye after strabismus surgery and associated risk factors.
A total of 84 eyes (48 children) that underwent strabismus surgery were included in the study. The mean age at surgery was 7.21 years. The incidence of dry eye was 47.62% at 1 week, 10.71% at 4 weeks, 0% at 8 weeks after surgery. The preoperative tear breakup time (BUT) was lower in the dry eye group than that in the non-dry eye group (P ≤ 0.01). The univariate analysis showed that preoperative BUT was significantly associated with the incidence of dry eye after pediatric strabismus surgery (odds ratio [OR] 0.647, confidence interval [CI] 0.503-0.833, P ≤ 0.01).
Dry eye commonly occurs after pediatric strabismus surgery. Tear film instability is more common than deficient aqueous tear production in patients with dry eye after surgery. Children with a low preoperative BUT are more likely to develop dry eye after strabismus surgery.
本研究旨在调查小儿斜视手术后干眼的发生率及危险因素。
本单中心前瞻性队列研究纳入了5至12岁接受斜视手术的儿童。在手术前1天以及手术后1周、4周和8周进行眼表评估。主要观察指标为斜视手术后干眼的发生率及相关危险因素。
本研究共纳入84只接受斜视手术的眼(48名儿童)。手术时的平均年龄为7.21岁。术后1周干眼发生率为47.62%,4周时为10.71%,8周时为0%。干眼组术前泪膜破裂时间(BUT)低于非干眼组(P≤0.01)。单因素分析显示,术前BUT与小儿斜视手术后干眼的发生率显著相关(比值比[OR]0.647,置信区间[CI]0.503 - 0.833,P≤0.01)。
小儿斜视手术后干眼较为常见。术后干眼患者中泪膜不稳定比泪液分泌不足更为常见。术前BUT较低的儿童斜视手术后更易发生干眼。