Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Hajiesmaeili Mohammadreza
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Cell Int. 2022 Oct 13;22(1):319. doi: 10.1186/s12935-022-02724-6.
LINC00467 is an example of long intergenic non-coding RNAs whose roles in human disorders are being identified. This gene coding LINC00467 is located on chromosome 1: 211,382,736 - 211,435,570 forward strand. This lncRNA has been firstly recognized through a microarray-based lncRNA profiling as an N-Myc target in neuroblastoma cells. Further studies have shown up-regulation of LINC00467 in different cancer including those originated from brain, gastrointestinal tract, lung and breast. It acts as a molecular sponge for miR-339, miR-138-5p, miR-107, miR-133b, miR-451a, miR-485-5p, miR-7-5p, miR-485-5p, miR-339-3p, miR-200a, miR-1285-3p, miR-299-5p, miR-509-3p, miR-18a-5p, miR-9-5p and miR-20b-5p. LINC00467 can regulate activity of NF-κB, STAT1, Wnt/b-catenin, Akt and ERK1/2 signaling pathways. Accumulating evidence indicates oncogenic role of LINC00467. The current review article aims at providing an overview of LINC00467 in the carcinogenesis.
LINC00467是长链基因间非编码RNA的一个例子，其在人类疾病中的作用正在被确定。编码LINC00467的这个基因位于1号染色体：211,382,736 - 211,435,570正义链上。这种长链非编码RNA首先通过基于微阵列的长链非编码RNA分析被识别为神经母细胞瘤细胞中的一个N-Myc靶点。进一步的研究表明，LINC00467在包括起源于脑、胃肠道、肺和乳腺的不同癌症中上调。它作为miR-339、miR-138-5p、miR-107、miR-133b、miR-451a、miR-485-5p、miR-7-5p、miR-485-5p、miR-339-3p、miR-200a、miR-1285-3p、miR-299-5p、miR-509-3p、miR-18a-5p、miR-9-5p和miR-20b-5p的分子海绵。LINC00467可以调节NF-κB、STAT1、Wnt/β-连环蛋白、Akt和ERK1/2信号通路的活性。越来越多的证据表明LINC00467具有致癌作用。本综述文章旨在概述LINC00467在致癌过程中的作用。
