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同期三尖瓣手术是否会增加微创二尖瓣手术的风险?基于荷兰心脏登记处数据的多中心比较。

Does concomitant tricuspid valve surgery increase the risks of minimally invasive mitral valve surgery? A multicentre comparison based on data from The Netherlands Heart Registration.

机构信息

Department of Cardiothoracic Surgery, Maastricht University Medical Centre, Maastricht, The Netherlands.

Department of Cardiothoracic Surgery, Catharina Hospital Eindhoven, Eindhoven, The Netherlands.

出版信息

J Card Surg. 2022 Dec;37(12):4362-4370. doi: 10.1111/jocs.17004. Epub 2022 Oct 13.

Abstract

OBJECTIVES

Mitral valve (MV) disease is often accompanied by tricuspid valve (TV) disease. The indication for concomitant TV surgery during primary MV surgery is expected to increase, especially through a minimally invasive surgical (MIS) approach. The aim of the current study is to investigate the safety of the addition of TV surgery to MV surgery in MIMVS in a nationwide registry.

METHODS

Patients undergoing atrioventricular valve surgery through sternotomy or MIS between 2013 and 2018 were included. Patients undergoing MV surgery only through sternotomy or MIS were used as comparison. Primary outcomes were short-term morbidity and mortality and long-term survival. Propensity score matching was used to correct for potential confounders.

RESULTS

The whole cohort consisted of 2698 patients. A total of 558 patients had atrioventricular double valve surgery through sternotomy and 86 through MIS. As a comparison, 1365 patients underwent MV surgery through sternotomy and 689 patients through MIS. No differences in 30- and 120-day mortality were observed between the groups, both unmatched and matched. 5-year survival did not differ for double atrioventricular valve surgery through either sternotomy or MIS in the matched population (90.1% vs. 95.3%, Log-Rank p = .12). A higher incidence of re-exploration for bleeding (n = 12 [15.2%] vs. n = 3 [3.8%], p = .02) and new onset arrhythmia (n = 35 [44.3%] vs. n = 13 [16.5%], p < .001) was observed in double valve surgery through MIS. Median length of hospital stay (LOHS) was longer in the minimally invasive double valve group (9 days [6-13]) compared with sternotomy (7 days [6-11]; p = .04).

CONCLUSION

No differences in short-term mortality and 5-year survival were observed when tricuspid valve was added to MV surgery in MIS or sternotomy. The addition of tricuspid valve surgery is associated with higher incidence of re-exploration for bleeding, new onset arrhythmia. A longer LOHS was observed for MIS compared to sternotomy.

摘要

目的

二尖瓣(MV)疾病常伴有三尖瓣(TV)疾病。预计在原发性 MV 手术中同时进行 TV 手术的适应证将会增加,尤其是通过微创外科(MIS)方法。本研究旨在通过全国注册研究,调查在微创二尖瓣成形术(MIMVS)中增加 TV 手术的安全性。

方法

纳入 2013 年至 2018 年期间经胸骨切开术或 MIS 行房室瓣手术的患者。将仅经胸骨切开术或 MIS 行 MV 手术的患者作为对照。主要结局为短期发病率和死亡率以及长期生存率。采用倾向评分匹配法纠正潜在混杂因素。

结果

全队列共纳入 2698 例患者。共有 558 例患者经胸骨切开术行房室瓣双瓣手术,86 例经 MIS 手术。作为对照,1365 例患者经胸骨切开术行 MV 手术,689 例经 MIS 手术。未匹配和匹配的两组在 30 天和 120 天死亡率方面无差异。在匹配人群中,经胸骨切开术或 MIS 行双房室瓣手术的 5 年生存率无差异(90.1% vs. 95.3%,Log-Rank p=0.12)。MIS 下行双瓣手术的患者中,再次开胸探查的发生率较高(12[15.2%]例 vs. 3[3.8%]例,p=0.02),新发心律失常的发生率较高(35[44.3%]例 vs. 13[16.5%]例,p<0.001)。微创双瓣组的中位住院时间(LOHS)较长(9 天[6-13]),与胸骨切开组相比(7 天[6-11];p=0.04)。

结论

在 MIS 或胸骨切开术同时行 MV 和 TV 手术时,短期死亡率和 5 年生存率无差异。TV 手术的附加与较高的再探查出血、新发心律失常发生率相关。与胸骨切开术相比,MIS 组的 LOHS 较长。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b090/10091696/cf5452ee7aaa/JOCS-37-4362-g001.jpg

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