Drigalenko E I, Ritsner M S
Genetika. 1987 May;23(5):892-7.
Based on ITO matrices, a method for parameter estimation of the monolocus diallele model (MDM) of qualitative trait is described, taking account of non-genetic (environmental) factors. The model parameters, probabilities of relatives' affection, constructing the likelihood function and testing hypotheses of the effect of environmental factors on the penetrations of MDM genotypes are outlined. Examples are given, concerning estimation of epilepsy MDM parameters, taking account of two factors-harmfulness of antenatal ontogenesis period and harmfulness which provokes paroxysms.
基于ITO矩阵，描述了一种定性性状单基因座双等位基因模型（MDM）的参数估计方法，该方法考虑了非遗传（环境）因素。概述了模型参数、亲属患病概率、构建似然函数以及检验环境因素对MDM基因型外显率影响的假设。给出了一些例子，涉及癫痫MDM参数的估计，其中考虑了两个因素——产前发育阶段的有害性和引发发作的有害性。
