Karas' S I
Genetika. 1988 Apr;24(4):732-40.
The results of studying the causes of prevalence and clinical polymorphism of schizophrenia on the basis of epidemiological selection of probands with paroxysmal-progredient form (211 families) have been presented in this paper. The analysis of multifactorial threshold and monolocus diallele models of factors of schizophrenia prevalence among relatives and in a population allowed to ground the hypothesis of the main gene. The characteristic manifestation is paroxysmal course of the process with small progredience and great specific weight of affective disorders. The increase of heterozygous genotype penetrance is linked to constitutional (somatotype, peculiarities of premorbid personality) and environmental (alcohol excesses, psychogenia) factors of probands.
本文介绍了基于对具有发作性-进行性形式的先证者（211个家庭）进行流行病学选择，研究精神分裂症患病率及临床多态性病因的结果。对亲属和人群中精神分裂症患病率因素的多因素阈值和单基因座双等位基因模型进行分析后，提出了主基因假说。其特征性表现为病程呈发作性，进展缓慢，情感障碍所占比重较大。杂合子基因型外显率的增加与先证者的体质（体型、病前人格特点）和环境（酗酒、精神因素）因素有关。
