泰国北部空气污染与急性肺栓塞患病率的相关性。
Correlation of Air Pollution and Prevalence of Acute Pulmonary Embolism in Northern Thailand.
机构信息
Division of Pulmonary, Critical Care, and Allergy, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
出版信息
Int J Environ Res Public Health. 2022 Oct 6;19(19):12808. doi: 10.3390/ijerph191912808.
BACKGROUND
The relationship between the level of air pollution and acute pulmonary embolism (APE) has had inconsistent results.
OBJECTIVE
This study aimed to analyze the relationship between the high level of air pollution exposure and APE.
METHODS
A ten-year retrospective cohort, single-center study was performed on patients diagnosed with APE from October 2010 to December 2020. The association between air pollution and monthly APE case diagnosis was analyzed.
RESULTS
A total number of 696 patients was included. The effect of every 10 µg/m increment of particulate matters with an aerodynamic diameter < 10 µm (PM) on total monthly APE cases (unprovoked PE and provoked PE) was increased significantly at lag 4, 5 and 6 months with adjusted RR (95% CI) of 1.06 (1.01, 1.12), = 0.011, 1.07 (1.01, 1.13), = 0.021 and 1.06 (1.01, 1.12), = 0.030, respectively. Adjusted RR for APE was significantly increased for PM in the second tertile ((adjusted RR (95% CI) 1.76 (1.12, 2.77)), = 0.014.
CONCLUSIONS
We conclude that PM is associated with an increased prevalence of APE cases. The policy for tighter control of air pollution in our country is needed to reduce the impact of air pollutants on people's health.
背景
空气污染水平与急性肺栓塞（APE）之间的关系一直存在不一致的结果。
目的
本研究旨在分析高水平空气污染暴露与 APE 之间的关系。
方法
对 2010 年 10 月至 2020 年 12 月期间诊断为 APE 的患者进行了一项为期十年的回顾性队列、单中心研究。分析了空气污染与每月 APE 病例诊断之间的关系。
结果
共纳入 696 例患者。在调整后的 RR（95%CI）分别为 1.06（1.01，1.12）， = 0.011、1.07（1.01，1.13）， = 0.021 和 1.06（1.01，1.12）， = 0.030 时，每增加 10µg/m3 的颗粒物（PM）（空气动力学直径<10µm）对总每月 APE 病例（特发性 PE 和诱发性 PE）的影响在滞后 4、5 和 6 个月时显著增加。PM 在第二三分位（调整后 RR（95%CI）1.76（1.12，2.77）， = 0.014）时，APE 的调整后 RR 显著增加。
结论
我们得出结论，PM 与 APE 病例的患病率增加有关。我国需要采取更严格的空气污染控制政策，以减少空气污染物对人们健康的影响。
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