Division of Hematology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Blood Bank Section, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Front Public Health. 2024 Jul 18;12:1410406. doi: 10.3389/fpubh.2024.1410406. eCollection 2024.
Elevated ambient pollution exposure is potentially linked to thromboembolism. However, the mechanisms by which particulate matter (PM) interferes with the balance of hemostatic system remain unclear. This study investigates PM-mediated hemostatic changes in individuals across unique seasonal variations of ambient pollution.
This prospective study was conducted between February and July 2020 during alterations in ambient pollution in Chiang Mai, Thailand. Blood tests from 30 healthy subjects were assessed at four-week intervals, four times in total. Various coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (aPTT), von Willebrand factor (vWF), platelet count, and platelet functions, were evaluated. A mixed-effects model was used to analyze the impact of high PM2.5 and PM10 on hemostatic parameters.
Thirty male subjects with mean age of 38.9 ± 8.2 years, were included. High levels of PM2.5 and PM10 were significantly associated with PT shortening, with no such effect observed in aPTT. PM2.5 and PM10 values also positively correlated with vWF function, while vWF antigen levels remained unchanged. Soluble P-selectin showed a strong positive association with PM2.5 and PM10 levels. Platelet function analysis revealed no correlation with PM values.
Short-term exposure to elevated PM2.5 and PM10 concentrations was linked to shortened PT and enhanced vWF function in healthy individuals. Exploring the impact of these changes on clinically relevant thrombosis is crucial. Additional studies on the pathogenesis of pollution-related thrombosis are warranted for maintaining good health.
环境污染物暴露水平升高可能与血栓栓塞有关。然而，颗粒物（PM）干扰止血系统平衡的机制尚不清楚。本研究调查了个体在环境污染物季节性变化期间 PM 介导的止血变化。
本前瞻性研究于 2020 年 2 月至 7 月在泰国清迈的环境污染物变化期间进行。在总共四次、四次间隔四周的时间里，对 30 名健康受试者的血液测试进行评估。评估了各种凝血测试，包括凝血酶原时间（PT）、活化部分凝血活酶时间（aPTT）、血管性血友病因子（vWF）、血小板计数和血小板功能。使用混合效应模型分析高 PM2.5 和 PM10 对止血参数的影响。
共纳入 30 名平均年龄为 38.9±8.2 岁的男性受试者。高水平的 PM2.5 和 PM10 与 PT 缩短显著相关，而 aPTT 则无此作用。PM2.5 和 PM10 值与 vWF 功能呈正相关，而 vWF 抗原水平保持不变。可溶性 P-选择素与 PM2.5 和 PM10 水平呈强正相关。血小板功能分析显示与 PM 值无相关性。
短期暴露于升高的 PM2.5 和 PM10 浓度与健康个体的 PT 缩短和 vWF 功能增强有关。探索这些变化对临床相关血栓形成的影响至关重要。需要进一步研究污染相关血栓形成的发病机制，以保持身体健康。
