Hojo Mariko, Nagahara Akihito, Kudo Takahiro, Takeda Tsutomu, Ikuse Tamaki, Matsumoto Kohei, Ueda Kumiko, Ueyama Hiroya, Matsumoto Kenshi, Asaoka Daisuke, Shimizu Toshiaki
Department of Gastroenterology Juntendo University School of Medicine Tokyo Japan.
Department of Pediatrics Juntendo University Faculty of Medicine Tokyo Japan.
JGH Open. 2021 Aug 27;5(10):1197-1202. doi: 10.1002/jgh3.12652. eCollection 2021 Oct.
We aimed to evaluate endoscopic findings of ()-positive children and young adults based on the Kyoto classification, and to examine if there are age-associated changes in -positive gastritis.
-positive patients under 40 years old who underwent upper gastrointestinal endoscopy from 1 April 2009 to 15 February 2017 were included. Subjects were classified into the Pediatric (<20 years) and Young adult groups (20-39 years). The patients' endoscopic photographs were retrospectively re-evaluated based on the Kyoto classification. We compared endoscopic findings between the two groups and examined alterations in the findings of -associated gastritis in 5-year age groups.
Forty-three and 163 subjects were classified into the Pediatric and Young adult groups, respectively. In the Pediatric group, nodularity was seen in the majority (93.0%); other endoscopic findings in order of decreasing frequency included mucosal swelling (32.6%), spotty redness (25.6%), diffuse redness (18.6%), and atrophy (9.3%). In the Young adult group, endoscopic findings included atrophy (66.9%), mucosal swelling (49.7%), spotty redness (39.3%), nodularity (31.9%), and diffuse redness (30.3%). The difference in prevalence of nodularity or atrophy between the two groups reached statistical significance ( < 0.0001 each). The rate of nodularity decreased with increasing age in the Young adult group. The rate of atrophy was 33% in young adult patients aged 20-24, and the rate increased to >65% in patients over age 25.
-positive children had endoscopic findings besides nodularity based on the Kyoto classification. The prevalence of atrophy increased in patients over age 20.
我们旨在基于京都分类法评估（）阳性儿童及年轻成人的内镜检查结果，并探讨（）阳性胃炎是否存在与年龄相关的变化。
纳入2009年4月1日至2017年2月15日期间接受上消化道内镜检查的40岁以下（）阳性患者。受试者分为儿童组（<20岁）和年轻成人组（20 - 39岁）。对患者的内镜照片进行回顾性重新评估，依据京都分类法进行分类。我们比较了两组的内镜检查结果，并研究了5岁年龄组中（）相关胃炎检查结果的变化。
分别有43名和163名受试者被归入儿童组和年轻成人组。在儿童组中，大多数（93.0%）可见结节状；其他内镜检查结果按频率递减依次为黏膜肿胀（32.6%）、斑片状发红（25.6%）、弥漫性发红（18.6%）和萎缩（9.3%）。在年轻成人组中，内镜检查结果包括萎缩（66.9%）、黏膜肿胀（49.7%）、斑片状发红（39.3%）、结节状（31.9%）和弥漫性发红（30.3%）。两组之间结节状或萎缩的患病率差异具有统计学意义（均<0.0001）。在年轻成人组中，结节状发生率随年龄增长而降低。20 - 24岁的年轻成人患者萎缩发生率为33%，25岁以上患者该发生率增至>65%。
基于京都分类法，（）阳性儿童除结节状外还有其他内镜检查结果。20岁以上患者萎缩患病率增加。
