Aupetit Alexandra, Grigioni Sébastien, Roman Horace, Coëffier Moïse, Bréant Amélie, Hennetier Clotilde, Achamrah Najate
Department of Gastroenterology, Rouen University Hospital, 37 Boulevard Gambetta, 76000 Rouen, France.
Department of Nutrition, Rouen University Hospital, 37 Boulevard Gambetta, 76000 Rouen, France.
J Clin Med. 2022 Sep 29;11(19):5773. doi: 10.3390/jcm11195773.
Background and aim: Irritable bowel syndrome (IBS), eating disorders (ED) and endometriosis share common pathophysiological mechanisms, involving alterations of the gut−brain axis. The aim of the ENDONUT pilot study was to investigate an association between these three diseases by screening for IBS and ED in patients with endometriosis. Method: We included patients from the CIRENDO cohort (Inter-Regional North-West Cohort of women with ENDOmetriosis) with a recent documented diagnosis of endometriosis of less than 4 years, regardless of age, date of onset of symptoms, type of endometriosis (digestive or not), with or without endometriosis-related digestive surgery. Validated questionnaires were used to screen for IBS (Rome IV, Francis score), ED (SCOFF-F, EAT-26), and anxiety/depression (HAD). Anthropometric data and lifestyle habits were also collected. The primary composite endpoint was SCOFF-F and ROME-IV scores. Results: Among 100 patients meeting inclusion criteria, 54 patients completed all the questionnaires. Of these, 19 had a positive SCOFF-F score (35.2%), 26 had a positive ROME-IV score (48.1%), and 14 patients (25.9%) had both a positive SCOFF-F score and a positive ROME-IV score (p = 0.006). Patients with positive SCOFF-F and ROME-IV scores had significantly higher HAD-anxiety and depression scores (p < 0.05). Conclusion: These results suggest a significant association between IBS, ED and endometriosis. The prevalence of IBS and ED in our population is higher than in the general population. Larger studies are needed to confirm these results, to better understand this triad, and to improve the diagnostic and multidisciplinary therapeutic management of these patients.
肠易激综合征（IBS）、饮食失调（ED）和子宫内膜异位症具有共同的病理生理机制，涉及肠-脑轴的改变。ENDONUT试点研究的目的是通过筛查子宫内膜异位症患者的IBS和ED来调查这三种疾病之间的关联。方法：我们纳入了CIRENDO队列（西北地区子宫内膜异位症女性区域间队列）中最近确诊为子宫内膜异位症且病程小于4年的患者，无论年龄、症状发作日期、子宫内膜异位症类型（是否为消化系统型），有无与子宫内膜异位症相关的消化系统手术史。使用经过验证的问卷筛查IBS（罗马IV，弗朗西斯评分）、ED（SCOFF-F，EAT-26）以及焦虑/抑郁（HAD）。还收集了人体测量数据和生活习惯。主要复合终点是SCOFF-F和罗马IV评分。结果：在100名符合纳入标准的患者中，54名患者完成了所有问卷。其中，19名患者SCOFF-F评分阳性（35.2%），26名患者罗马IV评分阳性（48.1%），14名患者（25.9%）SCOFF-F评分和罗马IV评分均为阳性（p = 0.006）。SCOFF-F和罗马IV评分阳性的患者HAD焦虑和抑郁评分显著更高（p < 0.05）。结论：这些结果表明IBS、ED和子宫内膜异位症之间存在显著关联。我们研究人群中IBS和ED的患病率高于一般人群。需要开展更大规模的研究来证实这些结果，以更好地理解这三者关系，并改善这些患者的诊断和多学科治疗管理。
