• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗性淀粉调节肠道微生物群并改善老年小鼠的肠道炎症。

Resistant Starch Modulate Gut Microbiota and Ameliorate Intestinal Inflammation in Aged Mice.

机构信息

Guangxi Vocational & Technical Institute of Industry, Nanning 530001, China.

College of Light Industry and Food Engineering, Guangxi University, Nanning 530004, China.

出版信息

Nutrients. 2022 Sep 22;14(19):3931. doi: 10.3390/nu14193931.

DOI:10.3390/nu14193931
PMID:36235583
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9572357/
Abstract

This study aimed to compare the regulatory effects of Arenga pinnata retrograded starch (APRS), Arenga pinnata starch (APS), and whole Arenga pinnata flour (APF) on gut microbiota and improvement of intestinal inflammation in aged mice. APF, APS, and APRS altered gut microbiota composition and exhibited different prebiotic effects. Bifidobacterium showed the greatest increase in feces of aged mice fed APF. The abundance of genus Lachnospiraceae_NK4A136 was highest in the APS group. APRS supplementation led to a greatest increasement in abundance of Lactobacillus, Roseburia, and Faecalibacterium prausnitzii. APRS induced significantly more short-chain fatty acid (SCFAs) production than APF and APS. APF, APS, and APRS treatments improved intestinal inflammation in aged mice and the order of ameliorative effect was APRS > APS > APF. APRS significantly decreased relative mRNA expression of pro-inflammatory cytokines (IL-6, IL-1β, and TNF-α) and increased anti-inflammatory cytokines (IL-10). In addition, APF, APS, and APRS significantly downregulated the relative mRNA expression of senescence-associated gene p53 and upregulated the expression of anti-aging gene Sirt1. These results provide potentially useful information about the beneficial effects of Arenga pinnata products on human health.

摘要

本研究旨在比较露兜树反刍淀粉（APRS）、露兜树淀粉（APS）和露兜树全粉（APF）对肠道微生物群的调节作用及其对老年小鼠肠道炎症的改善作用。APF、APS 和 APRS 改变了肠道微生物群组成，并表现出不同的益生元作用。双歧杆菌在饲喂 APF 的老年小鼠粪便中的增加最为明显。属 Lachnospiraceae_NK4A136 的丰度在 APS 组最高。APRS 补充剂导致乳酸杆菌、罗斯伯里氏菌和普拉氏梭菌丰度的最大增加。APRS 诱导的短链脂肪酸（SCFA）生成量明显高于 APF 和 APS。APF、APS 和 APRS 处理改善了老年小鼠的肠道炎症，其改善效果的顺序为 APRS > APS > APF。APRS 显著降低了促炎细胞因子（IL-6、IL-1β 和 TNF-α）的相对 mRNA 表达，增加了抗炎细胞因子（IL-10）的表达。此外，APF、APS 和 APRS 显著下调了衰老相关基因 p53 的相对 mRNA 表达，上调了抗衰老基因 Sirt1 的表达。这些结果为露兜树产品对人类健康的有益作用提供了有价值的信息。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/4f6a8bae6523/nutrients-14-03931-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/b6f1f865c740/nutrients-14-03931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/6cc3f3981691/nutrients-14-03931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/adc9b1080908/nutrients-14-03931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/3c95472d6b9f/nutrients-14-03931-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/b8db9b666ccd/nutrients-14-03931-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/65b3a58149f6/nutrients-14-03931-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/e44b2935338d/nutrients-14-03931-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/6c4f67c24c4f/nutrients-14-03931-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/4f6a8bae6523/nutrients-14-03931-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/b6f1f865c740/nutrients-14-03931-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/6cc3f3981691/nutrients-14-03931-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/adc9b1080908/nutrients-14-03931-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/3c95472d6b9f/nutrients-14-03931-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/b8db9b666ccd/nutrients-14-03931-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/65b3a58149f6/nutrients-14-03931-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/e44b2935338d/nutrients-14-03931-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/6c4f67c24c4f/nutrients-14-03931-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95bc/9572357/4f6a8bae6523/nutrients-14-03931-g009.jpg

相似文献

1
Resistant Starch Modulate Gut Microbiota and Ameliorate Intestinal Inflammation in Aged Mice.抗性淀粉调节肠道微生物群并改善老年小鼠的肠道炎症。
Nutrients. 2022 Sep 22;14(19):3931. doi: 10.3390/nu14193931.
2
Anti-nociceptive and anti-inflammatory effects of the ethanol extract of Arenga pinnata (Wurmb) Merr. fruit.菱果榈（Wurmb） Merr. 乙醇提取物的镇痛和抗炎作用。
J Ethnopharmacol. 2020 Feb 10;248:112349. doi: 10.1016/j.jep.2019.112349. Epub 2019 Nov 19.
3
Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity.白头翁汤通过调节粪便细菌相关的短链脂肪酸和肠道屏障完整性改善 DSS 诱导的结肠炎。
J Ethnopharmacol. 2023 Jan 10;300:115741. doi: 10.1016/j.jep.2022.115741. Epub 2022 Sep 24.
4
Lotus Seed Resistant Starch Regulates Gut Microbiota and Increases Short-Chain Fatty Acids Production and Mineral Absorption in Mice.莲子抗性淀粉调节小鼠肠道微生物群并增加短链脂肪酸生成及矿物质吸收
J Agric Food Chem. 2017 Oct 25;65(42):9217-9225. doi: 10.1021/acs.jafc.7b02860. Epub 2017 Oct 11.
5
Linarin ameliorates dextran sulfate sodium-induced colitis in C57BL/6J mice the improvement of intestinal barrier, suppression of inflammatory responses and modulation of gut microbiota.木犀草苷改善葡聚糖硫酸钠诱导的C57BL/6J小鼠结肠炎，改善肠道屏障、抑制炎症反应并调节肠道微生物群。
Food Funct. 2022 Oct 17;13(20):10574-10586. doi: 10.1039/d2fo02128e.
6
Soluble Dextrin Fibers Alter the Intestinal Microbiota and Reduce Proinflammatory Cytokine Secretion in Male IL-10-Deficient Mice.可溶性糊精纤维改变雄性白细胞介素-10缺陷小鼠的肠道微生物群并减少促炎细胞因子分泌。
J Nutr. 2015 Sep;145(9):2060-6. doi: 10.3945/jn.114.207738. Epub 2015 Jul 15.
7
Anti-inflammation effects of fucosylated chondroitin sulphate from Acaudina molpadioides by altering gut microbiota in obese mice.海洋生物多糖硫酸软骨素通过改变肥胖小鼠肠道微生物群发挥抗炎作用。
Food Funct. 2019 Mar 20;10(3):1736-1746. doi: 10.1039/c8fo02364f.
8
Dietary supplementation with soybean oligosaccharides increases short-chain fatty acids but decreases protein-derived catabolites in the intestinal luminal content of weaned Huanjiang mini-piglets.饲粮中添加大豆低聚糖增加断奶环江香猪肠道内容物短链脂肪酸，但降低蛋白质分解产物。
Nutr Res. 2014 Sep;34(9):780-8. doi: 10.1016/j.nutres.2014.08.008. Epub 2014 Aug 28.
9
Cross-linking Arenga pinnata starch and chitosan by citric acid: Structure and properties.柠檬酸交联琴叶榕淀粉和壳聚糖：结构与性能。
Int J Biol Macromol. 2024 Nov;280(Pt 4):136098. doi: 10.1016/j.ijbiomac.2024.136098. Epub 2024 Sep 28.
10
Honeys with anti-inflammatory capacity can alter the elderly gut microbiota in an ex vivo gut model.具有抗炎能力的蜂蜜可以在体外肠道模型中改变老年人的肠道微生物群。
Food Chem. 2022 Oct 30;392:133229. doi: 10.1016/j.foodchem.2022.133229. Epub 2022 May 18.

引用本文的文献

1
Inflammaging: The Next Challenge-Exploring the Role of Gut Microbiota, Environmental Factors, and Sex Differences.炎症衰老：下一个挑战——探索肠道微生物群、环境因素和性别差异的作用。
Biomedicines. 2024 Aug 1;12(8):1716. doi: 10.3390/biomedicines12081716.
2
Natural Shikonin Potentially Alters Intestinal Flora to Alleviate Acute Inflammation.天然紫草素可能通过改变肠道菌群来减轻急性炎症。
Microorganisms. 2023 Aug 23;11(9):2139. doi: 10.3390/microorganisms11092139.
3
Prebiotic mechanisms of resistant starches from dietary beans and pulses on gut microbiome and metabolic health in a humanized murine model of aging.

本文引用的文献

1
Centenarian-Sourced Combined with Dietary Fiber Complex Ameliorates Brain and Gut Function in Aged Mice.百岁老人源膳食纤维复合物改善老年小鼠的大脑和肠道功能。
Nutrients. 2022 Jan 13;14(2):324. doi: 10.3390/nu14020324.
2
Nutrition, Diet and Healthy Aging.营养、饮食与健康老龄化。
Nutrients. 2021 Dec 31;14(1):190. doi: 10.3390/nu14010190.
3
Succession Analysis of Gut Microbiota Structure of Participants from Long-Lived Families in Hechi, Guangxi, China.中国广西河池长寿家族参与者肠道微生物群结构的演替分析
在衰老的人源化小鼠模型中，膳食豆类和豆类抗性淀粉对肠道微生物群和代谢健康的益生元机制。
Front Nutr. 2023 Feb 7;10:1106463. doi: 10.3389/fnut.2023.1106463. eCollection 2023.
4
Components of the Fiber Diet in the Prevention and Treatment of IBD-An Update.膳食纤维在炎症性肠病防治中的作用：更新观点。
Nutrients. 2022 Dec 29;15(1):162. doi: 10.3390/nu15010162.
Microorganisms. 2021 Dec 7;9(12):2524. doi: 10.3390/microorganisms9122524.
4
Resistant starch, microbiome, and precision modulation.抗性淀粉、微生物组和精准调控。
Gut Microbes. 2021 Jan-Dec;13(1):1926842. doi: 10.1080/19490976.2021.1926842.
5
RS5 Produced More Butyric Acid through Regulating the Microbial Community of Human Gut Microbiota.RS5通过调节人类肠道微生物群的微生物群落产生更多丁酸。
J Agric Food Chem. 2021 Mar 17;69(10):3209-3218. doi: 10.1021/acs.jafc.0c08187. Epub 2021 Feb 25.
6
The Gut Microbiota and Unhealthy Aging: Disentangling Cause from Consequence.肠道微生物群与不健康的衰老：厘清因果关系。
Cell Host Microbe. 2020 Aug 12;28(2):180-189. doi: 10.1016/j.chom.2020.07.013.
7
Effect of in vitro digestion-fermentation of Ca(II)-alginate beads containing sugar and biopolymers over global antioxidant response and short chain fatty acids production.含糖和生物聚合物的 Ca(II)-海藻酸盐珠粒的体外消化-发酵对全球抗氧化反应和短链脂肪酸生成的影响。
Food Chem. 2020 Dec 15;333:127483. doi: 10.1016/j.foodchem.2020.127483. Epub 2020 Jul 7.
8
Dietary type 2 resistant starch improves systemic inflammation and intestinal permeability by modulating microbiota and metabolites in aged mice on high-fat diet.饮食型 2 抗性淀粉通过调节高脂肪饮食老龄小鼠的微生物群和代谢物来改善全身炎症和肠道通透性。
Aging (Albany NY). 2020 May 25;12(10):9173-9187. doi: 10.18632/aging.103187.
9
The Role of Short-Chain Fatty Acids From Gut Microbiota in Gut-Brain Communication.肠道微生物群产生的短链脂肪酸在肠-脑通讯中的作用
Front Endocrinol (Lausanne). 2020 Jan 31;11:25. doi: 10.3389/fendo.2020.00025. eCollection 2020.
10
A more pronounced effect of type III resistant starch vs. type II resistant starch on ameliorating hyperlipidemia in high fat diet-fed mice is associated with its supramolecular structural characteristics.与 II 型抗性淀粉相比，III 型抗性淀粉对高脂饮食喂养的小鼠改善高血脂的作用更明显，这与其超分子结构特征有关。
Food Funct. 2020 Mar 1;11(3):1982-1995. doi: 10.1039/c9fo02025j. Epub 2020 Feb 21.