Department of Health Sciences, College of Natural and Health Sciences, Zayed University (Dubai Campus), Dubai P.O. Box 19282, United Arab Emirates.
Department of Nutrition and Food Science, Faculty of Arts and Sciences, Lebanese International University, Beirut P.O. Box 146404, Lebanon.
Nutrients. 2022 Oct 6;14(19):4157. doi: 10.3390/nu14194157.
Vitamin D may be associated with irritable bowel syndrome (IBS) pathways. This cross-sectional study evaluated the associations between serum Vitamin D and IBS symptoms in a sample of Lebanese adults. Participants (n = 230; mean (SD) age: 43.36 (16.05) years, 62.9% females) were adults, free of diseases affecting Vitamin D metabolism, and recruited from a large university and the surrounding community. Serum Vitamin D (25-hydroxyvitamin D) was assessed using an automated chemiluminescence micro-particle immunoassay kit. The Birmingham IBS Symptom Questionnaire total scale, and pain, constipation, and diarrhea subscales were used to study IBS symptoms. Four linear regression analyses were performed, taking respectively the total scale and each of the subscales as the dependent variable. Vitamin D was forced into each model. Covariates included sociodemographic and medical variables, fluid intake, physical activity, sleep quality, stress, and adherence to the Mediterranean diet. Mean (SD) serum Vitamin D was 17.53 (12.40) ng/mL and mean (SD) Birmingham IBS Symptom Questionnaire was 16.98 (15.16) (pain: 20.75 (23.63), constipation: 25.06 (29.99), diarrhea: 9.88 (13.37)). Serum Vitamin D was not associated with the total score, nor with any of the subscales (p > 0.05 for the four regression analyses). Serum Vitamin D was not associated with IBS symptoms in a sample of Lebanese adults, adding to the controversy in this field. Further understanding of the pathophysiological mechanisms involved in Vitamin D and IBS is warranted.
维生素 D 可能与肠易激综合征 (IBS) 有关。本横断面研究评估了血清维生素 D 与黎巴嫩成年人样本中 IBS 症状之间的关系。参与者（n=230；平均（SD）年龄：43.36（16.05）岁，62.9%为女性）为成年人，无影响维生素 D 代谢的疾病，从一所大型大学和周边社区招募。使用自动化化学发光微粒子免疫测定试剂盒评估血清维生素 D（25-羟基维生素 D）。采用伯明翰 IBS 症状问卷总量表和疼痛、便秘和腹泻子量表研究 IBS 症状。进行了四项线性回归分析，分别以总量表和各子量表为因变量。将维生素 D 强行纳入每个模型。协变量包括社会人口统计学和医学变量、液体摄入、体力活动、睡眠质量、压力和对地中海饮食的依从性。血清维生素 D 的平均值（SD）为 17.53（12.40）ng/mL，伯明翰 IBS 症状问卷的平均值（SD）为 16.98（15.16）（疼痛：20.75（23.63），便秘：25.06（29.99），腹泻：9.88（13.37））。血清维生素 D 与总分或任何子量表均无相关性（四项回归分析的 p>0.05）。血清维生素 D 与黎巴嫩成年人样本中的 IBS 症状无关，这增加了该领域的争议。需要进一步了解维生素 D 和 IBS 相关的病理生理机制。
