Lusina Aleksandra, Nazim Tomasz, Cegłowski Michał
Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.
Polymers (Basel). 2022 Oct 5;14(19):4176. doi: 10.3390/polym14194176.
Poly(2-oxazoline)s are the synthetic polymers that are the products of the cationic ring-opening polymerization (CROP) of 2-oxazoline monomers. Due to their beneficial properties, from which biocompatibility, stealth behavior, high functionalization possibilities, low dispersity, stability, nonionic character, and solubility in water and organic solvents should be noted, they have found many applications and gained enormous interest from scientists. Additionally, with high versatility attainable through copolymerization or through post-polymerization modifications, this class of polymeric systems has been widely used as a polymeric platform for novel biomedical applications. The chemistry of polymers significant expanded into biomedical applications, in which polymeric networks can be successfully used in pharmaceutical development for tissue engineering, gene therapies, and also drug delivery systems. On the other hand, there is also a need to create 'smart' polymer biomaterials, responsive to the specified factor, that will be sensitive to various environmental stimuli. The commonly used stimuli-responsive biomedical materials are based mostly on temperature-, light-, magnetic-, electric-, and pH-responsive systems. Thus, creating selective and responsive materials that allow personalized treatment is in the interest of the scientific world. This review article focuses on recent discoveries by Polish scientists working in the field of stimuli-responsive poly(2-oxazoline)s, and their work is compared and contrasted with results reported by other world-renowned specialists.
聚（2-恶唑啉）是由2-恶唑啉单体通过阳离子开环聚合（CROP）得到的合成聚合物。由于其具有诸多优良特性，包括生物相容性、隐身性能、高功能化可能性、低分散性、稳定性、非离子特性以及在水和有机溶剂中的溶解性等，它们已获得了众多应用并引起了科学家们的极大兴趣。此外，通过共聚或后聚合改性可实现高度的多功能性，这类聚合物体系已被广泛用作新型生物医学应用的聚合物平台。聚合物化学在生物医学应用方面有了显著扩展，其中聚合物网络可成功应用于组织工程、基因治疗以及药物递送系统等药物研发领域。另一方面，也需要创制对特定因素有响应的“智能”聚合物生物材料，使其对各种环境刺激敏感。常用的刺激响应性生物医学材料主要基于温度、光、磁、电和pH响应体系。因此，创制能够实现个性化治疗的选择性和响应性材料是科学界所关注的。这篇综述文章聚焦于波兰科学家在刺激响应性聚（2-恶唑啉）领域的最新发现，并将他们的工作与其他世界知名专家报道的结果进行比较和对比。
