Compton M R, Seale J P, Shaw J
Int Arch Allergy Appl Immunol. 1987;84(1):40-4. doi: 10.1159/000234396.
Guinea pigs sensitized to produce IgG-like antibodies were challenged with aerosol antigen in vivo. The following day responses in vitro to histamine and carbachol of tracheal and lung parenchymal strips (LPS) from challenged animals and unchallenged controls were compared. Responses of LPS to both histamine and carbachol were increased in challenged animals but tracheal strips from challenged guinea pigs did not display increased sensitivity to histamine or carbachol compared with controls. Moreover, the sensitivity of tracheal strips to carbachol decreased in challenged animals. The increased sensitivity of LPS from challenged animals may be due to the release of chemical mediators and down regulation of postsynaptic muscarinic receptors may account for the decreased sensitivity of tracheal strips.
用气溶胶抗原对致敏产生IgG样抗体的豚鼠进行体内攻击。第二天，比较了攻击组动物和未攻击对照组的气管和肺实质条带（LPS）对组胺和卡巴胆碱的体外反应。攻击组动物的LPS对组胺和卡巴胆碱的反应均增强，但与对照组相比，攻击组豚鼠的气管条带对组胺或卡巴胆碱的敏感性并未增加。此外，攻击组动物的气管条带对卡巴胆碱的敏感性降低。攻击组动物LPS敏感性增加可能是由于化学介质的释放，而突触后毒蕈碱受体的下调可能是气管条带敏感性降低的原因。
