Zheng Sisi, Zeng Congcong, Huang Ailing, Huang Fuqi, Meng Anna, Wu Zhuan, Zhou Shouhong
Guangxi Key Laboratory of Brain and Cognitive Neuroscience, Guilin Medical University, Guilin, Guangxi 541199, P.R. China.
Central Laboratory, Guangxi Health Commission Key Laboratory of Glucose and Lipid Metabolism Disorders, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi 541199, P.R. China.
Biomed Rep. 2022 Sep 16;17(5):90. doi: 10.3892/br.2022.1572. eCollection 2022 Nov.
Protein arginine methyltransferases (PRMTs) are widely found in eukaryotes and regulate gene expression and post-translational modifications. PRMT1-PRMT6 have important roles in the pathology of cardiovascular diseases (CVDs), including atherosclerosis, heart failure and myocardial hypertrophy. Although these enzymes are also closely associated with various CVDs, the mechanisms of the involvement of PRMTs in the regulation of CVD have remained largely elusive. PRMTs methylate arginine residues and other factors. The present review describes the roles of PRMT1-PRMT6 in CVD. Furthermore, the biological characteristics of PRMTs and mechanisms by which PRMTs regulate cholesterol metabolism are being introduced. This review aims to provide inspiration for cardiovascular drug research and offer clues for research on the pathogenesis of CVD.
蛋白质精氨酸甲基转移酶（PRMTs）广泛存在于真核生物中，可调节基因表达和翻译后修饰。PRMT1 - PRMT6在心血管疾病（CVDs）的病理过程中发挥重要作用，包括动脉粥样硬化、心力衰竭和心肌肥大。尽管这些酶也与多种心血管疾病密切相关，但PRMTs参与心血管疾病调节的机制在很大程度上仍不清楚。PRMTs使精氨酸残基和其他因子发生甲基化。本综述描述了PRMT1 - PRMT6在心血管疾病中的作用。此外，还介绍了PRMTs的生物学特性以及PRMTs调节胆固醇代谢的机制。本综述旨在为心血管药物研究提供启发，并为心血管疾病发病机制的研究提供线索。
