Zhang Shun, Li Lu, Wang Jie, Zhang Tingting, Ye Ting, Wang Shuai, Xing Dongming, Chen Wujun
Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266071, China.
Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao Cancer Institute, Qingdao, Shandong 266071, China; School of Medical Imaging, Radiotherapy Department of Affiliated Hospital, Weifang Medical University, Weifang, Shandong 261053, China.
Clin Chim Acta. 2021 May;516:100-110. doi: 10.1016/j.cca.2021.01.019. Epub 2021 Feb 2.
Coronary heart disease (CHD) with atherosclerosis is the leading cause of death worldwide. ABCA1 and ABCG1 promote cholesterol efflux to suppress foam cell generation and reduce atherosclerosis development. Long noncoding RNAs (lncRNAs) are emerging as a unique group of RNA transcripts that longer than 200 nucleotides and have no protein-coding potential. Many studies have found that lncRNAs regulate cholesterol efflux to influence atherosclerosis development. ABCA1 is regulated by different lncRNAs, including MeXis, GAS5, TUG1, MEG3, MALAT1, Lnc-HC, RP5-833A20.1, LOXL1-AS1, CHROME, DAPK1-IT1, SIRT1 AS lncRNA, DYNLRB2-2, DANCR, LeXis, LOC286367, and LncOR13C9. ABCG1 is also regulated by different lncRNAs, including TUG1, GAS5, RP5-833A20.1, DYNLRB2-2, ENST00000602558.1, and AC096664.3. Thus, various lncRNAs are associated with the roles of ABCA1 and ABCG1 on cholesterol efflux in atherosclerosis regulation. However, some lncRNAs play dual roles in ABCA1 expression and atherosclerosis, and the functions of some lncRNAs in atherosclerosis have not been investigated in vivo. In this article, we review the roles of lncRNAs in atherosclerosis and focus on new insights into lncRNAs associated with the roles of ABCA1 and ABCG1 on cholesterol efflux and the potential of these lncRNAs as novel therapeutic targets in atherosclerosis.
伴有动脉粥样硬化的冠心病（CHD）是全球主要的死亡原因。ABCA1和ABCG1促进胆固醇外流，以抑制泡沫细胞生成并减少动脉粥样硬化的发展。长链非编码RNA（lncRNAs）作为一类独特的RNA转录本正在兴起，其长度超过200个核苷酸且没有蛋白质编码潜力。许多研究发现lncRNAs调节胆固醇外流以影响动脉粥样硬化的发展。ABCA1受不同lncRNAs调控，包括MeXis、GAS5、TUG1、MEG3、MALAT1、Lnc-HC、RP5-833A20.1、LOXL1-AS1、CHROME、DAPK1-IT1、SIRT1 AS lncRNA、DYNLRB2-2、DANCR、LeXis、LOC286367和LncOR13C9。ABCG1也受不同lncRNAs调控，包括TUG1、GAS5、RP5-833A20.1、DYNLRB2-2、ENST00000602558.1和AC096664.3。因此，各种lncRNAs与ABCA1和ABCG1在动脉粥样硬化调节中胆固醇外流的作用相关。然而，一些lncRNAs在ABCA1表达和动脉粥样硬化中发挥双重作用，并且一些lncRNAs在动脉粥样硬化中的功能尚未在体内进行研究。在本文中，我们综述了lncRNAs在动脉粥样硬化中的作用，并重点关注与ABCA1和ABCG1在胆固醇外流作用相关的lncRNAs的新见解以及这些lncRNAs作为动脉粥样硬化新治疗靶点的潜力。
