在缺氧条件下，一线抗菌药物对γ干扰素处理的沙眼衣原体的活性不同。
Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia.
机构信息
Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, Germany.
出版信息
Antimicrob Agents Chemother. 2013 Jun;57(6):2828-30. doi: 10.1128/AAC.02211-12. Epub 2013 Mar 11.
Abstract
Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.
摘要
γ干扰素（IFN-γ）介导的宿主反应在解决生殖道沙眼衣原体感染中起着核心作用，但也可能导致病原体持续存在，从而降低对抗微生物药物的敏感性。IFN-γ 的抗衣原体功能依赖于氧，在低氧环境中，对抗微生物药物对沙眼衣原体的疗效降低。在这项研究中，我们表明在低氧条件下，IFN-γ 处理的细胞中，阿奇霉素和强力霉素的抗衣原体疗效不同。
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