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在缺氧条件下，一线抗菌药物对γ干扰素处理的沙眼衣原体的活性不同。

Activities of first-choice antimicrobials against gamma interferon-treated Chlamydia trachomatis differ in hypoxia.

机构信息

Institute of Medical Microbiology and Hygiene, University of Lübeck, Lübeck, Germany.

出版信息

Antimicrob Agents Chemother. 2013 Jun;57(6):2828-30. doi: 10.1128/AAC.02211-12. Epub 2013 Mar 11.

DOI:10.1128/AAC.02211-12
PMID:23478971
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3716132/
Abstract

Gamma interferon (IFN-γ)-mediated host responses play a central role in resolving genital Chlamydia trachomatis infections but may also result in persistence of the pathogen, which shows reduced susceptibility to antimicrobials. The antichlamydial function of IFN-γ is oxygen dependent, and the efficacy of antimicrobials against C. trachomatis is reduced in a low-oxygen environment. In this study, we show that the antichlamydial efficacies of azithromycin and doxycycline differ in IFN-γ-treated cells under hypoxia.

摘要

γ干扰素（IFN-γ）介导的宿主反应在解决生殖道沙眼衣原体感染中起着核心作用，但也可能导致病原体持续存在，从而降低对抗微生物药物的敏感性。IFN-γ 的抗衣原体功能依赖于氧，在低氧环境中，对抗微生物药物对沙眼衣原体的疗效降低。在这项研究中，我们表明在低氧条件下，IFN-γ 处理的细胞中，阿奇霉素和强力霉素的抗衣原体疗效不同。

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Impact of a low-oxygen environment on the efficacy of antimicrobials against intracellular Chlamydia trachomatis.低氧环境对抗微生物药物治疗沙眼衣原体细胞内感染疗效的影响。
Antimicrob Agents Chemother. 2011 May;55(5):2319-24. doi: 10.1128/AAC.01655-10. Epub 2011 Feb 14.
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Protons make tumor cells move like clockwork.质子让肿瘤细胞像上了发条一样运动。
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Chlamydia trachomatis persistence: an update.沙眼衣原体持续性感染：最新进展
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Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88.沙眼衣原体诱导γ干扰素诱导蛋白10和β干扰素的表达，该过程不依赖Toll样受体2（TLR2）和Toll样受体4（TLR4），但很大程度上依赖髓样分化因子88（MyD88）。
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Antimicrob Agents Chemother. 2005 May;49(5):1787-93. doi: 10.1128/AAC.49.5.1787-1793.2005.