Department of Cardiology, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi 710018, China.
Department of Infection, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Xi'an, Shaanxi 710018, China.
Comput Math Methods Med. 2022 Sep 30;2022:6736225. doi: 10.1155/2022/6736225. eCollection 2022.
This research is aimed at investigating the relationship between liver fibrosis in viral hepatitis and macrophage colony-stimulating factor (M-CSF), tissue inhibitor of matrix metalloproteinase (TIMP-1), and ceruloplasmin (CER) in serum level.
Patients were randomly selected among those admitted to our hospital, and 60 healthy volunteers were chosen to serve as control participants. The levels of serum M-CSF, CER, and TIMP-1 were compared. According to the severity of their liver fibrosis, patients with CHB were separated into four groups: S1, S2, S3, and S4. Serum levels of M-CSF, CER, and TIMP-1 were correlated with liver fibrosis and hepatitis markers, and the diagnostic usefulness of the three indices was assessed with liver cirrhosis patients.
Increases in M-CSF and TIMP-1 in the CHB group but decreases in CER were statistically significant ( < 0.05). Serum levels of M-CSF, CER, TIMP-1, HA, PC-III, C-IV, and LN differed significantly across the four study groups ( < 0.05). Over time, as liver fibrosis worsened, we observed a progressive uptick in M-CSF, TIMP-1, LN, HA, C-IV, and PC-III levels and a progressive downtick in CER levels, with significant ( < 0.05) differences between the groups. There was a significant positive correlation between liver fibrosis and serum M-CSF, PC-III, TIMP-1, HA, LN, and C-IV levels in the CHB group ( < 0.05) and a significant negative correlation between serum CER and these same factors ( < 0.05). The AUC of 0.956 for diagnosing the S4 stage was greater than that of 0.857, 0.851, and 0.817 for M-CSF, CER, and TIMP-1, respectively.
In CHB patients, the liver fibrosis degree is associated with the M-CSF, CER, and TIMP-1 levels, and the combined clinical detection of these three markers has better diagnostic significance.
本研究旨在探讨病毒性肝炎肝纤维化与巨噬细胞集落刺激因子（M-CSF）、基质金属蛋白酶组织抑制剂-1（TIMP-1）和血清铜蓝蛋白（CER）之间的关系。
随机选取我院收治的患者作为研究对象，同时选取 60 名健康志愿者作为对照组。比较两组患者血清 M-CSF、CER 和 TIMP-1 水平。根据 CHB 患者肝纤维化程度分为 S1、S2、S3 和 S4 四组。分析血清 M-CSF、CER 和 TIMP-1 与肝纤维化及肝炎标志物的相关性，并评估三者联合对肝硬化的诊断价值。
CHB 组患者 M-CSF 和 TIMP-1 水平升高，CER 水平降低，差异有统计学意义（<0.05）。四组研究对象血清 M-CSF、CER、TIMP-1、HA、PC-III、C-IV 和 LN 水平比较，差异有统计学意义（<0.05）。随着肝纤维化程度的加重，M-CSF、TIMP-1、LN、HA、C-IV 和 PC-III 水平逐渐升高，CER 水平逐渐降低，各组间比较，差异均有统计学意义（<0.05）。CHB 组患者肝纤维化与血清 M-CSF、PC-III、TIMP-1、HA、LN 和 C-IV 呈正相关（<0.05），与 CER 呈负相关（<0.05）。M-CSF、CER、TIMP-1 对 S4 期的诊断 AUC 分别为 0.956、0.857、0.817，CER 的 AUC 大于 M-CSF、TIMP-1，差异均有统计学意义（<0.05）。
在 CHB 患者中，肝纤维化程度与 M-CSF、CER 和 TIMP-1 水平有关，联合检测这三种标志物具有更好的诊断意义。
