Green Austin R, Moshiri Ata, Hippe Daniel S, Raymundo Caroline, Piepkorn Michael, Shinohara Michi M
Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA.
Cancer Research Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
J Cutan Pathol. 2023 Jun;50(6):530-535. doi: 10.1111/cup.14341. Epub 2023 Apr 3.
Ongoing controversy exists regarding terminology used to describe atypical melanocytic nevi. Efforts to standardize nomenclature, including the 1992 NIH consensus conference, have been largely unsuccessful. Significant advances have revealed an increasingly detailed genetic picture of melanocytic neoplasms, including strong evidence for the existence of those with "intermediate" behavior.
We sent an electronic survey to dermatopathologists (n = 846) to assess trends in nomenclature usage and attitudes toward developing new consensus nomenclature for atypical melanocytic nevi.
There were 229 complete responses (27.1% response rate). The most used/preferred nomenclature was "dysplastic nevus" (43%/39%, respectively), followed by the NIH-recommended terminology (28%/26%). Three-tier grading systems were most heavily used/preferred (79%/63%). Dermatopathologists based in New England were most likely to use the NIH terminology; on the other hand, "dysplastic nevus" or "other" were most used elsewhere (p = 0.029). Most (76%) expressed at least "moderate" enthusiasm for developing consensus nomenclature, with 47% "very" or "extremely" enthusiastic.
Little has changed with the wide variation in terminology for atypical melanocytic nevi. There continues to be no one dominant terminology in use. However, there is enthusiasm for standardization. A new attempt at updated consensus nomenclature may be fruitful.
关于描述非典型黑素细胞痣的术语存在持续争议。包括1992年美国国立卫生研究院（NIH）共识会议在内的标准化命名法的努力在很大程度上并不成功。重大进展揭示了黑素细胞肿瘤越来越详细的基因图谱，包括有强有力的证据表明存在具有“中间”行为的肿瘤。
我们向皮肤病理学家（n = 846）发送了一份电子调查问卷，以评估命名法使用趋势以及对为非典型黑素细胞痣制定新的共识命名法的态度。
共收到229份完整回复（回复率27.1%）。使用最多/最偏好的命名法是“发育异常痣”（分别为43%/39%），其次是NIH推荐的术语（28%/26%）。三层分级系统使用最多/最受偏好（79%/63%）。新英格兰地区的皮肤病理学家最有可能使用NIH术语；另一方面，“发育异常痣”或“其他”在其他地区使用最多（p = 0.029）。大多数人（76%）对制定共识命名法至少表达了“中等”程度的热情，47%“非常”或“极其”热情。
非典型黑素细胞痣的术语广泛存在差异，几乎没有变化。目前仍然没有一种占主导地位的术语被广泛使用。然而，人们对标准化有热情。更新共识命名法的新尝试可能会取得成果。
