Finnish Institute for Health and Welfare, Helsinki, Finland.
ECDC Fellowship Programme, Field Epidemiology path (EPIET), European Centre for Disease Prevention and Control (ECDC), Solna, Sweden.
Euro Surveill. 2022 Oct;27(41). doi: 10.2807/1560-7917.ES.2022.27.41.2200316.
Several individuals reported gastrointestinal symptoms following meals consumed in late January 2021 at a restaurant in western Finland. We conducted a retrospective cohort study and defined a case as a person who ate at the lunch restaurant between 27 and 29 January 2021 and had stomach pain, vomiting or diarrhoea and/or a laboratory-confirmed Typhimurium infection within 2 weeks after the exposure. We collected faecal and food samples for microbiological analysis. isolates were characterised in detail using whole genome sequencing (WGS) and cluster analysis by core genome multilocus sequence typing (cgMLST). Altogether, 393 meals were sold and 101 people (who ate 142 meals) participated in the cohort study. There were 49 cases; 23 were laboratory-confirmed infections with a multidrug-resistant Typhimurium. The Typhimurium isolates from cases and frozen tomato cubes used uncooked in salads were closely related and clustered together in cgMLST comparison. These salads were consumed by 76% of the cases. Based on the cgMLST clustering, they were the suggested source of the outbreak. Statistical association was not significant between eating the salads and being a case. Following the outbreak investigation, the producer decided to recommend cooking of their frozen tomato products before consumption.
2021 年 1 月下旬，芬兰西部一家餐厅的部分顾客在用餐后出现胃肠道症状。我们开展了一项回顾性队列研究，将在 2021 年 1 月 27 日至 29 日午餐时段在该餐厅用餐，且在暴露后 2 周内出现腹痛、呕吐或腹泻和/或经实验室确认的肠炎沙门氏菌感染的人定义为病例。我们采集粪便和食物样本进行微生物分析。采用全基因组测序（WGS）和核心基因组多位点序列分型（cgMLST）的聚类分析对 分离株进行了详细特征描述。共售出 393 份餐食，有 101 人（共食用 142 份餐食）参与了队列研究。共有 49 例病例；23 例为经实验室确认的多重耐药肠炎沙门氏菌感染。病例和用于制作未煮熟沙拉的冷冻番茄块中的肠炎沙门氏菌分离株密切相关，在 cgMLST 比较中聚为一簇。这些沙拉被 76%的病例食用。基于 cgMLST 聚类，它们被认为是此次暴发的源头。病例食用沙拉与成为病例之间没有统计学关联。暴发调查后，生产商决定建议在食用其冷冻番茄产品前进行烹饪。
