Center for Genomic Science IIT@SEMM, Italian Institute of Technology, Milan 20139, Italy.
Department of Cellular, Computational and Integrative Biology - CIBIO, University of Trento, Trento 38123, Italy.
Biol Open. 2022 Oct 15;11(10). doi: 10.1242/bio.059597. Epub 2022 Oct 14.
Since the formalization of the Central Dogma of molecular biology, the relevance of RNA in modulating the flow of information from DNA to proteins has been clear. More recently, the discovery of a vast set of non-coding transcripts involved in crucial aspects of cellular biology has renewed the enthusiasm of the RNA community. Moreover, the remarkable impact of RNA therapies in facing the COVID19 pandemics has bolstered interest in the translational opportunities provided by this incredible molecule. For all these reasons, the Italian Society of Biophysics and Molecular Biology (SIBBM) decided to dedicate its 17th yearly meeting, held in June 2022 in Rome, to the many fascinating aspects of RNA biology. More than thirty national and international speakers covered the properties, modes of action and applications of RNA, from its role in the control of development and cell differentiation to its involvement in disease. Here, we summarize the scientific content of the conference, highlighting the take-home message of each presentation, and we stress the directions the community is currently exploring to push forward our comprehension of the RNA World 3.0.
自从分子生物学的中心法则正式确立以来，RNA 在调节从 DNA 到蛋白质的信息流方面的相关性已经很清楚了。最近，人们发现了大量涉及细胞生物学关键方面的非编码转录本，这重新激发了 RNA 领域的热情。此外，RNA 疗法在应对 COVID19 大流行方面的显著影响，增强了人们对这种神奇分子所提供的转化机会的兴趣。基于所有这些原因，意大利生物物理学和分子生物学学会（SIBBM）决定将其于 2022 年 6 月在罗马举行的第 17 届年会专门用于探讨 RNA 生物学的诸多迷人方面。三十多位国内外演讲者涵盖了 RNA 的特性、作用模式和应用，从其在发育和细胞分化控制中的作用到其在疾病中的参与。在这里，我们总结了会议的科学内容，突出了每个演讲的要点，并强调了该领域目前正在探索的方向，以推动我们对 RNA 世界 3.0 的理解。
