State Key Laboratory of Subtropical Silviculture, College of Forestry and Biotechnology, Zhejiang A&F University, Hangzhou 311300, China.
Int J Mol Sci. 2023 Jun 26;24(13):10664. doi: 10.3390/ijms241310664.
The central dogma of genetics, which outlines the flow of genetic information from DNA to RNA to protein, has long been the guiding principle in molecular biology. In fact, more than three-quarters of the RNAs produced by transcription of the plant genome are not translated into proteins, and these RNAs directly serve as non-coding RNAs in the regulation of plant life activities at the molecular level. The breakthroughs in high-throughput transcriptome sequencing technology and the establishment and improvement of non-coding RNA experiments have now led to the discovery and confirmation of the biogenesis, mechanisms, and synergistic effects of non-coding RNAs. These non-coding RNAs are now predicted to play important roles in the regulation of gene expression and responses to stress and evolution. In this review, we focus on the synthesis, and mechanisms of non-coding RNAs, and we discuss their impact on gene regulation in plants.
遗传学的中心法则概述了遗传信息从 DNA 到 RNA 再到蛋白质的流动，长期以来一直是分子生物学的指导原则。事实上，转录植物基因组产生的 RNA 中，有超过四分之三的 RNA 不被翻译成蛋白质，而这些 RNA 直接作为非编码 RNA 在分子水平上调节植物的生命活动。高通量转录组测序技术的突破以及非编码 RNA 实验的建立和改进，现在已经导致了非编码 RNA 的生物发生、机制和协同作用的发现和确认。这些非编码 RNA 现在被预测在调节基因表达和对胁迫及进化的反应中发挥重要作用。在这篇综述中，我们专注于非编码 RNA 的合成和机制，并讨论它们对植物基因调控的影响。
