高危子宫内膜癌中令人震惊的趋势和差异。
Alarming trends and disparities in high-risk endometrial cancer.
机构信息
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of California, Los Angeles.
Division of Gynecologic Oncology, Department of Surgery, City of Hope, Irvine, California, USA.
出版信息
Curr Opin Obstet Gynecol. 2023 Feb 1;35(1):15-20. doi: 10.1097/GCO.0000000000000832. Epub 2022 Oct 13.
PURPOSE OF REVIEW
To summarize the most recent publications highlighting the trends and disparities among patients diagnosed with high-risk endometrial cancer.
RECENT FINDINGS
Endometrial cancer mortality continues to rise, driven by the increasing incidence of high-risk histologic subtypes that accounts for a disproportionate number of endometrial cancer deaths. The lack of progress made in endometrial cancer treatment, particularly of high-risk histologic subtypes, disproportionately affects black women who are more likely to be diagnosed with these aggressive tumor types. Even when accounting for high-risk histology, various factors across the spectrum of care may influence the survival disparities between black and white women, including timely access to guideline-concordant care, clinical trial enrollment, and systemic racism that impacts cancer outcomes.
SUMMARY
In this review, we highlight the disproportionate impact of worsening endometrial cancer mortality and healthcare inequalities contributing to the endometrial cancer survival disparity between black and white women.
目的综述
总结最近发表的文献，强调高危子宫内膜癌患者的趋势和差异。
最近的发现
子宫内膜癌死亡率持续上升，主要是由于高危组织学亚型的发病率不断上升，而这些亚型在子宫内膜癌死亡病例中占了不成比例的数量。在子宫内膜癌治疗方面缺乏进展，特别是在高危组织学亚型方面，这对黑人妇女的影响不成比例，她们更有可能被诊断出这些侵袭性肿瘤类型。即使考虑到高危组织学，护理谱内的各种因素也可能影响黑人和白人妇女之间的生存差异，包括及时获得符合指南的护理、临床试验的参与以及影响癌症结果的系统性种族主义。
总结
在这篇综述中，我们强调了不断恶化的子宫内膜癌死亡率和医疗保健不平等对黑人和白人妇女之间子宫内膜癌生存差异的不成比例影响。
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