Institute of Epidemiology and Social Medicine, University of Münster, Munster, Germany.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
World J Biol Psychiatry. 2023 Jun;24(5):429-438. doi: 10.1080/15622975.2022.2129445. Epub 2022 Oct 14.
We examined (1) the proportion of cortisol awakening non-responders, (2) the association between cortisol awakening response (CAR) and trait resilience, and (3) the association between CAR increase and trait resilience in two patient cohorts (depression and myocardial infarction [CVD]) and one population-based cohort.
Eight hundred and eighty study participants delivered CAR scores (response and increase) based on three self-collected saliva samples and a trait resilience score. Descriptive data of CAR non-responders were reported and calculated. Associations between CAR response/increase and trait resilience, sociodemographic and compliance variables were evaluated using multiple logistic and multiple linear regression analyses stratified by cohort.
The proportion of CAR non-responders was high in all cohorts (57% depression cohort, 53.4% CVD cohort, 51.6% control cohort). In the depression cohort age was associated with CAR response and increase. In the CVD cohort salivary collection on a weekday was associated with CAR response and awakening time with CAR increase. In the control cohort age was associated with CAR response and sex with CAR increase.
We observed many CAR non-responders and significant associations between CAR response and CAR increase with single sociodemographic and compliance variables. We did not find significant relationships between CAR response or increase and trait resilience.
我们研究了（1）皮质醇觉醒反应无应答者的比例，（2）皮质醇觉醒反应（CAR）与特质弹性之间的关系，以及（3）在两个患者队列（抑郁症和心肌梗死[CVD]）和一个基于人群的队列中，CAR 增加与特质弹性之间的关系。
880 名研究参与者根据三个自我收集的唾液样本和一个特质弹性评分提供了 CAR 评分（反应和增加）。报告并计算了 CAR 无应答者的描述性数据。使用多元逻辑回归和多元线性回归分析，按队列分层评估了 CAR 反应/增加与特质弹性、社会人口统计学和依从性变量之间的关系。
所有队列的 CAR 无应答者比例均较高（抑郁症队列为 57%，CVD 队列为 53.4%，对照组为 51.6%）。在抑郁症队列中，年龄与 CAR 反应和增加有关。在 CVD 队列中，工作日唾液采集与 CAR 反应有关，觉醒时间与 CAR 增加有关。在对照组中，年龄与 CAR 反应有关，性别与 CAR 增加有关。
我们观察到许多 CAR 无应答者，以及 CAR 反应和 CAR 增加与单个社会人口统计学和依从性变量之间存在显著关联。我们没有发现 CAR 反应或增加与特质弹性之间存在显著关系。
